Azadirachtin derivatives from seed kernels of Azadirachta excelsa

  • J Nat Prod. 2005 Jul;68(7):1047-50. doi: 10.1021/np050064t.
Somdej Kanokmedhakul  1 ,  Kwanjai Kanokmedhakul ,  Thirada Prajuabsuk ,  Sanha Panichajakul ,  Piyanan Panyamee ,  Samran Prabpai ,  Palangpon Kongsaeree
Affiliations
  • 1. Department of Chemistry, Taxonomic Research Center, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. [email protected]
PMID: 16038546 DOI: 10.1021/np050064t
Abstract

Three new azadirachtin derivatives, named azadirachtins O-Q (1-3), along with the known azadirachtin B (4), azadirachtin L (5), azadirachtin M (6) 11alpha-azadirachtin H (7), 11beta-azadirachtin H (8), and azadirachtol (9) were isolated from seed kernels of Azadirachta excelsa. Their structures were established by spectroscopic techniques, and the structure of 3 was confirmed by X-ray analysis. Compounds 1-7 and 9 exhibited toxicity to the diamondback moth (Plutella xylostella) with an LD50 of 0.75-1.92 microg/g body weight, in 92 h.

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