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Art. -Nr.: HY-152034

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STING-IN-5

Name: STING-IN-5
Brand: MedChemExpress
SKU: HY-152034
Price: 305.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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STING-IN-5 is a potent STING inhibitor, inhibiting LPS-induced NO synthesis in macrophages with an IC₅₀ value of 1.15 μM. STING-IN-5 inhibits the inflammatory response. STING-IN-5 can be used to research anti-inflammatory diseases and sepsis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 99.89%
CAS. Nr.: 2920064-17-9
Formel: C₄₇H₆₇NO₉S₂
Molecular Weight:854.17

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

STING-IN-5 Chemical Structure

CAS. Nr.: 2920064-17-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

STING-IN-5 (compound 30) (40 μM; 24 h) exhibits less effect on RAW264.7 cell viability^[1].
STING-IN-5 (2.5 and 5 μM; 2 h) inhibits NO production in LPS-stimulated RAW264.7 with inhibition rate of 69.28 ± 2.36 and 78.66 ± 2.73 at 2.5 and 5 μM, respectively, and exhibits IC₅₀ of 1.15 ± 0.15 μM^[1].
STING-IN-5 (0.5-2 μM; 2 h) suppresses STING, as well as TBK1/IRF3/NF-κB activation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

RAW264.7
Concentration:

40 μM
Incubation Time:

24 h
Result:

Exhibited less effect on RAW264.7 cell viability of 91.08 ± 1.09%

Western Blot Analysis^[1]

Cell Line:

RAW264.7 (stimulated by LPS for 6 h)
Concentration:

0.5, 1 and 2 μM
Incubation Time:

2 h
Result:

Significantly inhibited the protein expression of STING and the phosphorylation of the downstream targets TBK1, IRF3, p65, and IκB in a concentration-dependent manner.

In Vivo

STING-IN-5 (1.25-5 mg/kg; i.g.; once daily; for 3 days) have an obvious protective effect on acute liver injury in septic mice^[1].
Pharmacokinetic Parameters of STING-IN-5 in male Sprague-Dawley rats^[1].

T_max (h)	C_max (ng/mL)	AUC_0-t (ng/mL·h)	AUC_0-∞ (ng/mL·h)	T_1/2 (h)	MRT_0-t (h)	MRT_0-∞ (h)
1	66.52	81.08	135.7	1.11	0.99	2.02

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male BALB/c mice (6-8 weeks; acute liver injury induced by injection of 10 mg/kg LPS)^[1]
Dosage:

1.25, 2.5, 5 mg/kg
Administration:

i.g.; once daily; for 3 days
Result:

Significantly improved pathological changes including disorderly arranged liver cells, blurred boundaries, congested hepatic sinusoids, swollen hepatocytes, a small number of hepatocytes were necrotic, and inflammatory cells infiltrated local areas.
Significantly reduced the levels of AST, ALT, and ALP (liver function specific indicators).

Chemical Information

CAS. Nr. 2920064-17-9
Appearance Solid
Molecular Weight 854.17
Formel C₄₇H₆₇NO₉S₂
Color White to off-white
SMILES

C[C@H]([C@H](OC(CCSSCCC(NOCC=C)=O)=O)CC[C@@]1([C@@]2([C@@H](C[C@]3(/C4=C(CC/C=C(C)/C)\C(OCC5=CC=CC=C5)=O)[H])O)[H])C)[C@@]1(CC[C@]2(C)[C@@]3(C)C[C@@H]4OC(C)=O)[H]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (117.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1707 mL

5.8536 mL

11.7073 mL

5 mM

0.2341 mL

1.1707 mL

2.3415 mL

10 mM

0.1171 mL

0.5854 mL

1.1707 mL

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Long J, et al. Discovery of fusidic acid derivatives as novel STING inhibitors for treatment of sepsis. Eur J Med Chem. 2022 Dec 15;244:114814. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.1707 mL	5.8536 mL	11.7073 mL	29.2682 mL
	5 mM	0.2341 mL	1.1707 mL	2.3415 mL	5.8536 mL
	10 mM	0.1171 mL	0.5854 mL	1.1707 mL	2.9268 mL
	15 mM	0.0780 mL	0.3902 mL	0.7805 mL	1.9512 mL
	20 mM	0.0585 mL	0.2927 mL	0.5854 mL	1.4634 mL
	25 mM	0.0468 mL	0.2341 mL	0.4683 mL	1.1707 mL
	30 mM	0.0390 mL	0.1951 mL	0.3902 mL	0.9756 mL
	40 mM	0.0293 mL	0.1463 mL	0.2927 mL	0.7317 mL
	50 mM	0.0234 mL	0.1171 mL	0.2341 mL	0.5854 mL
	60 mM	0.0195 mL	0.0976 mL	0.1951 mL	0.4878 mL
	80 mM	0.0146 mL	0.0732 mL	0.1463 mL	0.3659 mL
	100 mM	0.0117 mL	0.0585 mL	0.1171 mL	0.2927 mL

Bioz

Keywords

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Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

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CAS. Nr.:
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Reinheit:
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STING-IN-5

Biologische Aktivität

Beschreibung

In Vitro

In Vivo

Chemical Information

Lösungsmittel & Löslichkeit

In Vitro:

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

STING-IN-5 Related Classifications

HY-152034 Related Classifications

Bioz

Keywords

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