Anti-inflammatory agent 66
Anti-inflammatory agent 66 (compound 8) is a pterostilbene derivative with anti-inflammatory activity. Anti-inflammatory agent 66 inhibits pro-inflammatory cytokines by blocking the LPS-induced NF-κB/MAPK signaling pathway and effectively alleviates DSS-induced acute colitis in mice.
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- Formel: C24H25ClN4O4
- Molecular Weight:468.93
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
>50 μM
Compound: 8
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Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 20 uM incubated for 24 hrs in absence of LPS by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 20 uM incubated for 24 hrs in absence of LPS by MTT assay
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[PMID: 37989058] |
| RAW264.7 | IC50 |
>50 μM
Compound: 8
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Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 20 uM incubated for 24 hrs in presence of LPS by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 20 uM incubated for 24 hrs in presence of LPS by MTT assay
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[PMID: 37989058] |
| RAW264.7 | IC50 |
0.6 μM
Compound: 8
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Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated pretreated with compound for 1 hr followed by LPS-induction and measured after 24 hrs by Griess reagent based assay
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated pretreated with compound for 1 hr followed by LPS-induction and measured after 24 hrs by Griess reagent based assay
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[PMID: 37989058] |
Chemical Information
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Molecular Weight 468.93
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Formel C24H25ClN4O4
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SMILES
C=CCOC1=CC=C(/C=C/C2=CC(OC)=CC(OC)=C2C3=CN=NN3C(NCCCl)=O)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Anti-inflammatory agent 66 Related Classifications
HY-157211 Related Classifications
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