Anti-inflammatory agent 66
Anti-inflammatory agent 66 (compound 8) is a pterostilbene derivative with anti-inflammatory activity. Anti-inflammatory agent 66 inhibits pro-inflammatory cytokines by blocking the LPS-induced NF-κB/MAPK signaling pathway and effectively alleviates DSS-induced acute colitis in mice.
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- Formule: C24H25ClN4O4
- Masse moléculaire:468.93
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
>50 μM
Compound: 8
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Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 20 uM incubated for 24 hrs in absence of LPS by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 20 uM incubated for 24 hrs in absence of LPS by MTT assay
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[PMID: 37989058] |
| RAW264.7 | IC50 |
>50 μM
Compound: 8
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Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 20 uM incubated for 24 hrs in presence of LPS by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 20 uM incubated for 24 hrs in presence of LPS by MTT assay
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[PMID: 37989058] |
| RAW264.7 | IC50 |
0.6 μM
Compound: 8
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Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated pretreated with compound for 1 hr followed by LPS-induction and measured after 24 hrs by Griess reagent based assay
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated pretreated with compound for 1 hr followed by LPS-induction and measured after 24 hrs by Griess reagent based assay
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[PMID: 37989058] |
Chemical Information
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Masse moléculaire 468.93
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Formule C24H25ClN4O4
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SMILES
C=CCOC1=CC=C(/C=C/C2=CC(OC)=CC(OC)=C2C3=CN=NN3C(NCCCl)=O)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-inflammatory agent 66 Related Classifications
HY-157211 Related Classifications
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