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  3. Bromelain

Bromelain 

Cat. No.: HY-129611
Handling Instructions

Bromelain is an anti-inflammatory drug derived from pineapple stem that acts through down-regulation of plasma kininogen, inhibition of Prostaglandin E2 expression, degradation of advanced glycation end product receptors and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX-pathway. Bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death.

For research use only. We do not sell to patients.

Bromelain Chemical Structure

Bromelain Chemical Structure

CAS No. : 9001-00-7

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Estimated Time of Arrival: December 31
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Description

Bromelain is an anti-inflammatory drug derived from pineapple stem that acts through down-regulation of plasma kininogen, inhibition of Prostaglandin E2 expression, degradation of advanced glycation end product receptors and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX-pathway[1]. Bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death[2].

In Vivo

Bromelain (40 mg/kg; intraperitoneal injection; daily; for 7 days; male Sprague-Dawley rats) pretreatment reduces the motor dysfunction in the parkinsonian rat model of parkinson's disease (PD). 6-OHDA injection resulted in marked motor impairment which is prevented by pretreatment with Bromelain prior to the lesion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats injected with 6-OHDA[1]
Dosage: 40 mg/kg
Administration: Intraperitoneal injection; daily; for 7 days
Result: Reduced the motor dysfunction in the parkinsonian rat model of parkinson's disease (PD).
Clinical Trial
CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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Bromelain
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