1. PI3K/Akt/mTOR
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  3. 3,4,5-Tricaffeoylquinic acid

3,4,5-Tricaffeoylquinic acid (Synonyms: 3,4,5-triCQA)

Cat. No.: HY-N6588
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3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases.

For research use only. We do not sell to patients.

3,4,5-Tricaffeoylquinic acid Chemical Structure

3,4,5-Tricaffeoylquinic acid Chemical Structure

CAS No. : 86632-03-3

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Description

3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases[1][2].

In Vitro

3,4,5-Tricaffeoylquinic acid (0-50 μM) reduces TNF-α-induced production of cytokines in HEK001 keratinocytes[1].
3,4,5-Tricaffeoylquinic acid (15 μM, 35 min) inhibits TNF-α-induced IkBα phosphorylation and activation of NF-κB[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Keratinocytes
Concentration: 15, 25 and 50 μM
Incubation Time: 24 hours
Result: Cell death was cell ∼4-5% at 15 and 25 μM, ∼9% at 50 μM.

Western Blot Analysis[1]

Cell Line: Keratinocytes
Concentration: 15 μM
Incubation Time: 20 min before 10 ng/mL TNF-α addition for 15 min
Result: Decreased TNF-α-induced-IkBα phosphorylation of IkBα and levels of cytosolic NF-Κb p65, cytosolic NF-Κb p65.
Molecular Weight

678.59

Formula

C₃₄H₃₀O₁₅

CAS No.
SMILES

O=C([[email protected]]1(O)C[[email protected]@H](OC(/C=C/C2=CC=C(O)C(O)=C2)=O)[[email protected]@H](OC(/C=C/C3=CC=C(O)C(O)=C3)=O)[[email protected]](OC(/C=C/C4=CC=C(O)C(O)=C4)=O)C1)O

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Keywords:

3,4,5-Tricaffeoylquinic acid3,4,5-triCQAAktNF-κBPKBProtein kinase BNuclear factor-κBNuclear factor-kappaBinflammatorykeratinocytescytoskeletonchromatinremodelingneuronalbonemorphogeneticagingInhibitorinhibitorinhibit

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