3,4,5-Tricaffeoylquinic acid
Based on 1 Customer Validation
3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases.
For research use only. We do not sell to patients.
- Purity: 98.15%
- CAS No.: 86632-03-3
- Formula: C34H30O15
- Molecular Weight:678.59
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
3,4,5-Tricaffeoylquinic acid (0-50 μM) reduces TNF-α-induced production of cytokines in HEK001 keratinocytes[1].
3,4,5-Tricaffeoylquinic acid (15 μM, 35 min) inhibits TNF-α-induced IkBα phosphorylation and activation of NF-κB[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Keratinocytes
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Concentration:15, 25 and 50 μM
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Incubation Time:24 hours
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Result:Cell death was cell ∼4-5% at 15 and 25 μM, ∼9% at 50 μM.
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Cell Line:Keratinocytes
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Concentration:15 μM
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Incubation Time:20 min before 10 ng/mL TNF-α addition for 15 min
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Result:Decreased TNF-α-induced-IkBα phosphorylation of IkBα and levels of cytosolic NF-Κb p65, cytosolic NF-Κb p65.
Chemical Information
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CAS No. 86632-03-3
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Appearance Solid
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Molecular Weight 678.59
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Formula C34H30O15
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Color Yellow to brown
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SMILES
O=C([C@]1(O)C[C@@H](OC(/C=C/C2=CC=C(O)C(O)=C2)=O)[C@@H](OC(/C=C/C3=CC=C(O)C(O)=C3)=O)[C@H](OC(/C=C/C4=CC=C(O)C(O)=C4)=O)C1)O
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Synonyms
3,4,5-triCQA
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL (73.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Lee CS, et al. 3,4,5-Tricaffeoylquinic acid inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. Int Immunopharmacol. 2011;11(11):1715-1723. [Content Brief]
[2]. Sasaki K, et al. 3,4,5-Tricaffeoylquinic acid induces adult neurogenesis and improves deficit of learning and memory in aging model senescence-accelerated prone 8 mice. Aging (Albany NY). 2019;11(2):401-422. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4736 mL | 7.3682 mL | 14.7364 mL | 36.8411 mL |
| 5 mM | 0.2947 mL | 1.4736 mL | 2.9473 mL | 7.3682 mL | |
| 10 mM | 0.1474 mL | 0.7368 mL | 1.4736 mL | 3.6841 mL | |
| 15 mM | 0.0982 mL | 0.4912 mL | 0.9824 mL | 2.4561 mL | |
| 20 mM | 0.0737 mL | 0.3684 mL | 0.7368 mL | 1.8421 mL | |
| 25 mM | 0.0589 mL | 0.2947 mL | 0.5895 mL | 1.4736 mL | |
| 30 mM | 0.0491 mL | 0.2456 mL | 0.4912 mL | 1.2280 mL | |
| 40 mM | 0.0368 mL | 0.1842 mL | 0.3684 mL | 0.9210 mL | |
| 50 mM | 0.0295 mL | 0.1474 mL | 0.2947 mL | 0.7368 mL | |
| 60 mM | 0.0246 mL | 0.1228 mL | 0.2456 mL | 0.6140 mL |
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