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3,4-Dicaffeoylquinic acid

(Synonyms: 3,4-Di-O-caffeoylquinic acid; Isochlorogenic acid B)
10 Cited Publications
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Based on 10 publication(s) in Google Scholar

3,4-Dicaffeoylquinic acid (3,4-Di-O-caffeoylquinic acid), naturally isolated from Laggera alata, has antioxidative, DNA protective, neuroprotective and hepatoprotective properties. 3,4-Dicaffeoylquinic acid exerts apoptosis-mediated cytotoxicity and α-glucosidase inhibitory effects. 3,4-Dicaffeoylquinic acid possesses a unique mechanism of anti-influenza viral activity, that is, enhancing viral clearance by increasing TRAIL.

For research use only. We do not sell to patients.

  • Purity: 98.15%
  • CAS No.: 14534-61-3
  • Formula: C25H24O12
  • Molecular Weight:516.45
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • 3,4-Dicaffeoylquinic acid Chemical Structure
    3,4-Dicaffeoylquinic acid Chemical Structure
  • Experimental Validation Results for 3,4-Dicaffeoylquinic acid
  • Experimental Validation Results for 3,4-Dicaffeoylquinic acid
  • Experimental Validation Results for 3,4-Dicaffeoylquinic acid
  • Experimental Validation Results for 3,4-Dicaffeoylquinic acid
  • Experimental Validation Results for 3,4-Dicaffeoylquinic acid
CAS No.: 14534-61-3
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  • 3,4-Dicaffeoylquinic acid Chemical Structure
    3,4-Dicaffeoylquinic acid Chemical Structure
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    3,4-Dicaffeoylquinic acid purchased from MedChemExpress. Usage Cited in: Nat Aging. 2024 Sep;4(9):1231-1248. [Abstract]

    Customer Validation
     Quantification of SA-β-Gal assay of UV-B-irradiated IMR90 fibroblasts, treated with the indicated compounds (3,4-Dicaffeoylquinic acid (Dicaffeoylquinic acid), etc.) at 1 μM concentration or 10 μg/mL for HK.

  • 1/16

    3,4-Dicaffeoylquinic acid purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Nov 14;13(1):210. [Abstract]

    Customer Validation
     Examination of the inhibition capability of caffeine, CGA, isoCGA-A, isoCGA-B (3,4-Dicaffeoylquinic acid) (1-5 μM; 1 h), isoCGA-C, methylferulic acid and luteolin against the entry of wild-type SARS-CoV-2 on 293 T-ACE2 cells by Vpp (MOI = 0.1).

  • 1/16

    3,4-Dicaffeoylquinic acid purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Nov 14;13(1):210. [Abstract]

    Customer Validation
     Co-immunoprecipitation using 293 T cells expressing SARS-CoV-2 spike-HA and ACE2 to verify that 5 compounds can inhibit the binding of ACE2 and spike. After anti-HA pulldown, adding 5 compounds (3,4-Dicaffeoylquinic acid (IsoCGA-B), etc.) (100 μM; 1 h), ACE2, and spike antibodies were used to detect by immunoblotting.

  • 1/16

    3,4-Dicaffeoylquinic acid purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Nov 14;13(1):210. [Abstract]

    Customer Validation
     Validation of the ability of caffeine, CGA, isoCGA-A, isoCGA-B (3,4-Dicaffeoylquinic acid) (1h), and isoCGA-C at 0, 25, 50, 100, and 200 μM to repress TMPRSS2 activity using a cell-based TMPRSS2 enzyme activity assay.

  • 1/16

    3,4-Dicaffeoylquinic acid purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Nov 14;13(1):210. [Abstract]

    Customer Validation
     Through Western blot to test 5 compounds (3,4-Dicaffeoylquinic acid (IsoCGA-B) (1 h), etc.) at 100 μM impact cleavage of SARS-CoV-2 S by TMPRSS2.

  • 3,4-Dicaffeoylquinic acid