Collagenase inhibitory quinic acid esters from Ipomoea pes-caprae

  • J Nat Prod. 2005 May;68(5):794-6. doi: 10.1021/np0500631.
Fumihiro Teramachi  1 ,  Takashi Koyano ,  Thaworn Kowithayakorn ,  Masahiko Hayashi ,  Kanki Komiyama ,  Masami Ishibashi
Affiliations
  • 1. Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
PMID: 15921434 DOI: 10.1021/np0500631
Abstract

Two new quinic acid esters (1 and 2) were isolated from the extract of Ipomoea pes-caprae together with six known quinic acid esters (3-8). The structures of compounds 1 and 2 were elucidated by spectroscopic data interpretation. These new compounds exhibited collagenase inhibitory activity and showed almost no cytotoxicity.