1. Autophagy
    Metabolic Enzyme/Protease
  2. Autophagy
    Tyrosinase
  3. Taxifolin

Taxifolin (Synonyms: (+)-Dihydroquercetin; (+)-Taxifolin)

Cat. No.: HY-N0136 Purity: 99.97%
Handling Instructions

Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.

For research use only. We do not sell to patients.

Taxifolin Chemical Structure

Taxifolin Chemical Structure

CAS No. : 480-18-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
50 mg USD 50 In-stock
Estimated Time of Arrival: December 31
100 mg USD 80 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of Taxifolin:

Top Publications Citing Use of Products

    Taxifolin purchased from MCE. Usage Cited in: Appl Microbiol Biotechnol. 2018 Feb;102(3):1443-1453.

    Dihydroquercetin relieves APAP-induced necrosis and suppressed ERK/JNK stress responses. Western Blot analysis for phosphor-JNK1/2, β-Actin as a lading control.
    • Biological Activity

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    • Customer Review

    Description

    Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].

    IC50 & Target

    IC50: 193.3 μM (Collagenase)[1]
    Tyrosinase[1]

    In Vitro

    This is confirmed by the investigation of pure Taxifolin and (+)-Catechin against collagenase activity. Taxifolin exhibits significant inhibitory activity with an IC50 value of 193.3 μM while (+)-Catechin is not active[1]. Taxifolin is a ubiquitous bioactive constituent of foods and herbs. Taxifolin (dihydroquercetin) is a bioactive flavanonol commonly found in grapes, citrus fruits, onions, green tea, olive oil, wine, and many other foods, as well as several herbs (such as milk thistle, French maritime bark, Douglas fir bark, and Smilacis Glabrae Rhizoma)[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Taxifolin may be easily metabolized and that its metabolites are the prevalent form in vivo, although limited information is available on metabolism of Taxifolin in vivo[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    304.25

    Formula

    C₁₅H₁₂O₇

    CAS No.

    480-18-2

    SMILES

    O=C1[[email protected]](O)[[email protected]@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (328.68 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2868 mL 16.4339 mL 32.8677 mL
    5 mM 0.6574 mL 3.2868 mL 6.5735 mL
    10 mM 0.3287 mL 1.6434 mL 3.2868 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.75 mg/mL (9.04 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.75 mg/mL (9.04 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.75 mg/mL (9.04 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    Animal Administration
    [3]

    Rats[3]
    Twelve male Sprague-Dawley rats (weighing 180-220 g) are used. The rats are randomly divided into two groups (six rats per group), a drug group and a blank group. Taxifolin is suspended in 0.5% CMC-Na solution and orally administered to the drug group at a dose of 200 mg/kg body weight, while blank group rats are orally administered 0.5% CMC-Na solution at the same volume. All rats are dosed once a day (at 9:00 a.m.) for 3 days.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References

    Purity: 99.97%

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    Keywords:

    Taxifolin(+)-Dihydroquercetin (+)-TaxifolinAutophagyTyrosinaseantifibroticantioxidantInhibitorinhibitorinhibit

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