2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Anti-infection
  3. Reactive Oxygen Species Influenza Virus
  4. Cynarin

Cynarin is an antichoke agent with a variety of biological activities including antioxidant, antihistamic and antiviral activities.

For research use only. We do not sell to patients.

Cynarin Chemical Structure

Cynarin Chemical Structure

CAS No. : 30964-13-7

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 97 In-stock
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10 mM * 1 mL in DMSO USD 97 In-stock
Solid
1 mg USD 50 In-stock
5 mg USD 85 In-stock
10 mg USD 140 In-stock
25 mg USD 260 In-stock
50 mg USD 390 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Cynarin:

Cynarin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Cynarin

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Cynarin is an antichoke agent with a variety of biological activities including antioxidant, antihistamic and antiviral activities.

In Vitro

Cynarin inhibits taste receptors, making water to be sweet. It has been shown to have some pharmacological properties including hypocholesterolemic, hepatoprotective, antiviral, antibacterial, and antihistamic effects. Cynarin has marked antioxidant, anticholinergic, reducing ability, radical-scavenging, and metal-binding activities. Cynarin demonstrates 87.72% inhibition of linoleic acid lipid peroxidation at 30 mg/mL concentration. Cynarin exhibits effective DMPD+, ABTS+, O2-, DPPH1, and H2O2 scavenging effects, reducing capabilities and Fe2+ chelating effects. IC50 and Ki of cynarin for acetylcholinesterase enzyme inhibition are 243.67nM and 39.34±13.88 nM, respectively[1]. Cynarin is a potential immunosuppressant that blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells. Cynarin blocks about 87% of the CD28-dependent "signal 2" pathway of T-cell activation under the condition of one to one ratio of T-cell and B-cell. Cynarin binds to the "G-pocket" of CD28 and thus interrupts the site of interaction between CD28 and CD80[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cynarin Related Antibodies
Molecular Weight

516.45

Formula

C25H24O12
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C([C@]1(OC(/C=C/C2=CC=C(O)C(O)=C2)=O)C[C@@H](OC(/C=C/C3=CC=C(O)C(O)=C3)=O)[C@@H](O)[C@H](O)C1)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 23 mg/mL (44.53 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9363 mL 9.6815 mL 19.3630 mL
5 mM 0.3873 mL 1.9363 mL 3.8726 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
Cell Assay
[2]

The cytotoxicity of cynarin treatment of T-cells is measured by MTT colorimetric assay. 100 μL Jurkat cells are incubated with cynarin (0-1000 μg/mL) for 24 h at 37°C. The cell solution is then centrifuged and the supernatant removed. 200 μL of MTT is added and the cell solution is incubated again for 4 h at 37°C. 200 μL of DMSO lysis buffer is added into the cell medium and the concentration of dissolved MTT crystals is measured by plate reader at 560 nm[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9363 mL 9.6815 mL 19.3630 mL 48.4074 mL
5 mM 0.3873 mL 1.9363 mL 3.8726 mL 9.6815 mL
10 mM 0.1936 mL 0.9681 mL 1.9363 mL 4.8407 mL
15 mM 0.1291 mL 0.6454 mL 1.2909 mL 3.2272 mL
20 mM 0.0968 mL 0.4841 mL 0.9681 mL 2.4204 mL
25 mM 0.0775 mL 0.3873 mL 0.7745 mL 1.9363 mL
30 mM 0.0645 mL 0.3227 mL 0.6454 mL 1.6136 mL
40 mM 0.0484 mL 0.2420 mL 0.4841 mL 1.2102 mL
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Cynarin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cynarin30964-13-7CynarineReactive Oxygen SpeciesInfluenza VirusInhibitorinhibitorinhibit

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