2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Anti-infection
  3. Reactive Oxygen Species (ROS) Influenza Virus
  4. Cynarin

Cynarin is an antichoke agent with a variety of biological activities including antioxidant, antihistamic and antiviral activities.

For research use only. We do not sell to patients.

CAS No. : 30964-13-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Cynarin:

Cynarin Related Antibodies

Top Publications Citing Use of Products

    Cynarin purchased from MedChemExpress. Usage Cited in: Anim Cells Syst. 2022 May 20;26(3):119-128.

    Cell viability of EA.hy926 cells after treatment with different Cynarin (1, 2, 5, 10 μM) concentrations as determined using the cell counting kit-8 assay.

    Cynarin purchased from MedChemExpress. Usage Cited in: Anim Cells Syst. 2022 May 20;26(3):119-128.

    EA.hy926 cells were treated with Cynarin (1, 2, 5 μM) for 4 h before adding LPS (1 μg/mL) for another 24 h. VCAM-1 expression level was measured via western blotting.

    Cynarin purchased from MedChemExpress. Usage Cited in: Anim Cells Syst. 2022 May 20;26(3):119-128.

    The mRNA expression levels of inflammatory genes [monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor (TNF-α), and interleukin (IL)−1β] as detected via real-time PCR treated with Cynarin (1, 5 μM).

    Cynarin purchased from MedChemExpress. Usage Cited in: Anim Cells Syst. 2022 May 20;26(3):119-128.

    The cells were treated with Cynarin (5 µM) for 1 h before adding LPS (1 μg/mL) for another 30 min. Representative immunofluorescence staining images showing NF-κB p65 (green) and the nucleus (blue).

    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Cynarin is an antichoke agent with a variety of biological activities including antioxidant, antihistamic and antiviral activities.

    Cellular Effect
    Cell Line Type Value Description References
    MT2 ED50
    4 μM
    Compound: 1,5-DCQA
    Concentration that inhibits Human Immunodeficiency Virus Type 1 (HIV-1)-induced death of MT-2 cells
    Concentration that inhibits Human Immunodeficiency Virus Type 1 (HIV-1)-induced death of MT-2 cells
    		[PMID: 9986720]
    In Vitro

    Cynarin inhibits taste receptors, making water to be sweet. It has been shown to have some pharmacological properties including hypocholesterolemic, hepatoprotective, antiviral, antibacterial, and antihistamic effects. Cynarin has marked antioxidant, anticholinergic, reducing ability, radical-scavenging, and metal-binding activities. Cynarin demonstrates 87.72% inhibition of linoleic acid lipid peroxidation at 30 mg/mL concentration. Cynarin exhibits effective DMPD+, ABTS+, O2-, DPPH1, and H2O2 scavenging effects, reducing capabilities and Fe2+ chelating effects. IC50 and Ki of cynarin for acetylcholinesterase enzyme inhibition are 243.67nM and 39.34±13.88 nM, respectively[1]. Cynarin is a potential immunosuppressant that blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells. Cynarin blocks about 87% of the CD28-dependent "signal 2" pathway of T-cell activation under the condition of one to one ratio of T-cell and B-cell. Cynarin binds to the "G-pocket" of CD28 and thus interrupts the site of interaction between CD28 and CD80[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cynarin Related Antibodies
    Molecular Weight

    516.45

    Formula

    C25H24O12
    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    O=C([C@]1(OC(/C=C/C2=CC=C(O)C(O)=C2)=O)C[C@@H](OC(/C=C/C3=CC=C(O)C(O)=C3)=O)[C@@H](O)[C@H](O)C1)O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 250 mg/mL (484.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9363 mL 9.6815 mL 19.3630 mL
    5 mM 0.3873 mL 1.9363 mL 3.8726 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.80%

    SDS (393 KB)

    COA (247 KB) HNMR (298 KB) LCMS (96 KB)

    Handling Instructions (2659 KB)
    References
    Cell Assay
    [2]

    The cytotoxicity of cynarin treatment of T-cells is measured by MTT colorimetric assay. 100 μL Jurkat cells are incubated with cynarin (0-1000 μg/mL) for 24 h at 37°C. The cell solution is then centrifuged and the supernatant removed. 200 μL of MTT is added and the cell solution is incubated again for 4 h at 37°C. 200 μL of DMSO lysis buffer is added into the cell medium and the concentration of dissolved MTT crystals is measured by plate reader at 560 nm[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.9363 mL 9.6815 mL 19.3630 mL 48.4074 mL
    5 mM 0.3873 mL 1.9363 mL 3.8726 mL 9.6815 mL
    10 mM 0.1936 mL 0.9681 mL 1.9363 mL 4.8407 mL
    15 mM 0.1291 mL 0.6454 mL 1.2909 mL 3.2272 mL
    20 mM 0.0968 mL 0.4841 mL 0.9681 mL 2.4204 mL
    25 mM 0.0775 mL 0.3873 mL 0.7745 mL 1.9363 mL
    30 mM 0.0645 mL 0.3227 mL 0.6454 mL 1.6136 mL
    40 mM 0.0484 mL 0.2420 mL 0.4841 mL 1.2102 mL
    50 mM 0.0387 mL 0.1936 mL 0.3873 mL 0.9681 mL
    60 mM 0.0323 mL 0.1614 mL 0.3227 mL 0.8068 mL
    80 mM 0.0242 mL 0.1210 mL 0.2420 mL 0.6051 mL
    100 mM 0.0194 mL 0.0968 mL 0.1936 mL 0.4841 mL
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    Cynarin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Cynarin30964-13-7CynarineReactive Oxygen Species (ROS)Influenza VirusInhibitorinhibitorinhibit

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