1. Anti-infection
    PI3K/Akt/mTOR
    Apoptosis
  2. HCV
    Parasite
    Akt
    Ferroptosis
  3. Artemisinin

Artemisinin (Synonyms: Qinghaosu; NSC 369397)

Cat. No.: HY-B0094 Purity: >98.0%
Handling Instructions

Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial drug isolated from the aerial parts of Artemisia annua L. plants. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects.

For research use only. We do not sell to patients.

Artemisinin Chemical Structure

Artemisinin Chemical Structure

CAS No. : 63968-64-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
200 mg USD 72 In-stock
Estimated Time of Arrival: December 31
500 mg USD 108 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Artemisinin

    Artemisinin purchased from MCE. Usage Cited in: Biomed Pharmacother. 2019 Aug.

    ART (Artemisinin) suppresses the phosphorylation of AKT in UMRC-2 xenograft tumor. Tumors are homogenized in RIPA buffer. The protein levels were measured by western blot analysis.

    View All Akt Isoform Specific Products:

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial drug isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].

    IC50 & Target[2]

    pAKT

     

    In Vitro

    Artemisinin (Qinghaosu) (25 or 50 μM; 24 hours) concentration-dependently suppresses Aβ25-35 induced cytotoxicity in PC12 cells[1].
    Artemisinin (1-100 μM; 24  hours) selectively inhibits cancer cell growth in a dose-dependent manner with IC50 values of 31.30 ± 0.73 μM in UMRC-2 cells and 23.97 ± 0.92 CAKI-2 cells[2].
    Artemisinin (25, 50 μM; 24 hours) suppresses the phosphorylation of AKT in UMRC-2 and CAKI-2 cells in a dose-dependent manner[2].

    Cell Cytotoxicity Assay[1]

    Cell Line: PC12 cells
    Concentration: 25 or 50 μM
    Incubation Time: 24 hours
    Result: Protected and rescue PC12 cells against Aβ25-35-induced cell death.

    Cell Viability Assay[2]

    Cell Line: RCC cells, RCC cell lines UMRC-2 and CAKI-2, and normal renal cell HK-2
    Concentration: 1, 5, 10, 50, and 100 μM
    Incubation Time: 24 hours
    Result: Selectively inhibited cancer cell growth in a dose-dependent manner.

    Western Blot Analysis[2]

    Cell Line: UMRC-2 and CAKI-2 cells
    Concentration: 25, 50 μM
    Incubation Time: 24 hours
    Result: Decreased pAKT in a dose-dependent manner.
    In Vivo

    Artemisinin (gavage; 20 mg/kg/day; for two weeks) suppresses UMRC-2 xenograft tumor growth[2].

    Animal Model: 4-6 weeks old male nude mice[2]
    Dosage: 20 mg/kg
    Administration: gavage; every day for two weeks
    Result: Suppressed UMRC-2 xenograft tumor growth.
    Clinical Trial
    Molecular Weight

    282.33

    Formula

    C₁₅H₂₂O₅

    CAS No.

    63968-64-9

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (177.10 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.5420 mL 17.7098 mL 35.4195 mL
    5 mM 0.7084 mL 3.5420 mL 7.0839 mL
    10 mM 0.3542 mL 1.7710 mL 3.5420 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    ArtemisininQinghaosuNSC 369397NSC369397NSC-369397HCVParasiteAktFerroptosisHepatitis C virusPKBProtein kinase BInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product name

     

    Salutation

    Applicant name *

     

    Email address *

    Phone number *

     

    Organization name *

    Country or Region *

     

    Requested quantity *

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product name:
    Artemisinin
    Cat. No.:
    HY-B0094
    Quantity:
    MCE Japan Authorized Agent: