2. PI3K/Akt/mTOR
  3. Akt
  4. ZINC00640089

ZINC00640089 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00640089 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. ZINC00640089 has good potential for research in inflammatory breast cancer (IBC).

For research use only. We do not sell to patients.

CAS No. : 667880-11-7

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Based on 8 publication(s) in Google Scholar

ZINC00640089 Related Antibodies

Top Publications Citing Use of Products

    ZINC00640089 purchased from MedChemExpress. Usage Cited in: ACS Chem Neurosci. 2025 Jul 2;16(13):2546-2558.  [Abstract]

    ZINC00640089 (ZIN; 5 mg/kg; 200 μL; IP; once per 2 days up to the 28th day) in male C57BL/6J wild-type mice (200 nL of type IV collagenase (0.05 U) was injected into the thalamus ). Thermal (50 °C) and mechanical (0.07 and 0.4 g) allodynia were detected before and after TH induction. ZIN significantly worsened TH-induced allodynia.

    ZINC00640089 purchased from MedChemExpress. Usage Cited in: ACS Chem Neurosci. 2025 Jul 2;16(13):2546-2558.  [Abstract]

    ZINC00640089 (ZIN; 5 mg/kg; 200 μL; IP; once per 2 days up to the 28th day) in male C57BL/6J wild-type mice (200 nL of type IV collagenase (0.05 U) was injected into the thalamus). Representative images and statistical analysis of the expression of c-fos on somatosensory regions of the cortex.

    ZINC00640089 purchased from MedChemExpress. Usage Cited in: ACS Chem Neurosci. 2025 Jul 2;16(13):2546-2558.  [Abstract]

    Effect of Oba and ZINC00640089 (LCN2 inhibitors) on the phagocytic effect of astrocytes on synapses, inflammatory responses, and ferroptosis within the thalamic region 28 days after TH. Representative images and statistical analysis of the localization of (A) MERTK and (B) Homer1 on astrocytes (GFAP). ZINC00640089 (ZIN; 5 mg/kg; 200 μL; IP; once per 2 days up to the 28th day) in male C57BL/6J wild-type mice (200 nL of type IV collagenase (0.05 U) was injected into the thalamus).

    ZINC00640089 purchased from MedChemExpress. Usage Cited in: Clin Exp Med. 2025 Aug 21;25(1):297.  [Abstract]

    P21 and P16 expression levels were assessed after LPS (1 μg/mL; 24 h) stimulation in the presence or absence of either the ZINC00640089 (LCN2 inhibitor) or 4-HPR in Caco-2 cells.

    ZINC00640089 purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2025 Sep 27:505:117579.  [Abstract]

    After exposing MLE12 cells to ZINC00640089 (10 μM) for 48 h, E-cadherin and Vimentin protein expression was quantified by Western blotting.

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    Description

    ZINC00640089 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00640089 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. ZINC00640089 has good potential for research in inflammatory breast cancer (IBC)[1].

    IC50 & Target

    LCN2[1].
    In Vitro

    ZINC00640089 (0.01-100 μM; 72 h) reduces cell proliferation and cell viability in SUM149 cells[1].
    ZINC00640089 (1, 10 μM; 15 min, 1 h) reduces the p-Akt levels in SUM149 cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    ZINC00640089 Related Antibodies

    Cell Viability Assay[1]

    Cell Line: SUM149 cells
    Concentration: 0.01-100 µM
    Incubation Time: 72 h
    Result: Reduced cell viability at concentrations of 1 µM or lower.

    Western Blot Analysis[1]

    Cell Line: SUM149 cells
    Concentration: 1, 10 µM
    Incubation Time: 15 min, 1 h, 24 h
    Result: Reduced the p-Akt protein levels 15 min and 1 h and changes in the p-Akt protein levels were not observed at 24 h.
    Molecular Weight

    370.33

    Formula

    C20H13F3N2O2
    CAS No.
    Appearance

    Solid

    Color

    Off-white to yellow

    SMILES

    O=C(CN1C(C2=C3C1=CC=CC3=CC=C2)=O)NC4=C(C(F)(F)F)C=CC=C4
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 8 mg/mL (21.60 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7003 mL 13.5015 mL 27.0029 mL
    5 mM 0.5401 mL 2.7003 mL 5.4006 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Purity & Documentation

    Purity: 99.95%

    SDS (252 KB)

    COA (256 KB) HNMR (261 KB) CNMR (225 KB) RP-HPLC (415 KB) LCMS (111 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.7003 mL 13.5015 mL 27.0029 mL 67.5074 mL
    5 mM 0.5401 mL 2.7003 mL 5.4006 mL 13.5015 mL
    10 mM 0.2700 mL 1.3501 mL 2.7003 mL 6.7507 mL
    15 mM 0.1800 mL 0.9001 mL 1.8002 mL 4.5005 mL
    20 mM 0.1350 mL 0.6751 mL 1.3501 mL 3.3754 mL
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    ZINC00640089 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    ZINC00640089667880-11-7ZINC 00640089ZINC-00640089AktPKBProtein kinase BIBCinflammatory breast cancerAKTproliferationSUM149 cellInhibitorinhibitorinhibit

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