Cat. No.: HY-Q45780

ZINC00640089

9 Cited Publications

Customer Review

Based on 9 publication(s) in Google Scholar

ZINC00640089 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00640089 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. ZINC00640089 has good potential for research in inflammatory breast cancer (IBC).

For research use only. We do not sell to patients.

Purity: 99.76%
CAS No.: 667880-11-7
Formula: C₂₀H₁₃F₃N₂O₂
Molecular Weight:370.33

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

ZINC00640089 Chemical Structure

CAS No.: 667880-11-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (9)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

LCN2^[1].

All Akt Isoforms :

In Vitro

ZINC00640089 (0.01-100 μM; 72 h) reduces cell proliferation and cell viability in SUM149 cells^[1].
ZINC00640089 (1, 10 μM; 15 min, 1 h) reduces the p-Akt levels in SUM149 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

SUM149 cells
Concentration:

0.01-100 µM
Incubation Time:

72 h
Result:

Reduced cell viability at concentrations of 1 µM or lower.

Western Blot Analysis^[1]

Cell Line:

SUM149 cells
Concentration:

1, 10 µM
Incubation Time:

15 min, 1 h, 24 h
Result:

Reduced the p-Akt protein levels 15 min and 1 h and changes in the p-Akt protein levels were not observed at 24 h.

Chemical Information

CAS No. 667880-11-7
Appearance Solid
Molecular Weight 370.33
Formula C₂₀H₁₃F₃N₂O₂
Color Off-white to yellow
SMILES

O=C(CN1C(C2=C3C1=CC=CC3=CC=C2)=O)NC4=C(C(F)(F)F)C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (9)

All WBIn Vivo Efficacy StudyRT-PCR

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Journal Impact Factor

Adv Sci (Weinh)

ROS-Responsive Wedelolactone Hydrogel Promotes Intervertebral Disc Repair by Disrupting the NF-κB-LCN2 Inflammatory Feedback Loop. [Abstract]

2026 Mar;13(14):e21709. PMID: 41487054
Cell Rep Med

CAR-M2 immunotherapy resolves renal fibrosis via revascularization and apoptosis of profibrotic Cxcr2+ endothelial cells. [Abstract]

2026 Apr 21;7(4):102698. PMID: 41887221
Phytomedicine

Handelin inhibits osteoclastogenesis and bone loss by targeting lipocalin-2 and restoring autophagy to suppress NF-κB signaling. [Abstract]

2026 Jul 25:157:158331. PMID: 42229383
Redox Rep

Artesunate ameliorates experimental autoimmune uveitis by inhibiting the LCN2-STAT3 axis and suppressing microglial activation. [Abstract]

2026 Dec;31(1):2627096. PMID: 41674301
J Inflamm Res

Gandouling Regulates Ferroptosis and Improves Neuroinflammation in Wilson's Disease Through the LCN2/NLRP3 Signaling Pathway. [Abstract]

2024 Aug 23:17:5599-5618. PMID: 39193124
Clin Exp Med

The association between 4-HPR-mediated LCN2 suppression and reduced intestinal cell senescence in ulcerative colitis. [Abstract]

2025 Aug 21;25(1):297. PMID: 40839227

ZINC00640089 purchased from MedChemExpress. Usage Cited in: Clin Exp Med. 2025 Aug 21;25(1):297. [Abstract]

P21 and P16 expression levels were assessed after LPS (1 μg/mL; 24 h) stimulation in the presence or absence of either the ZINC00640089 (LCN2 inhibitor) or 4-HPR in Caco-2 cells.
ACS Chem Neurosci

Obacunone Alleviates Thalamic Pain via Promoting LCN2-Mediated Phagocytosis of Astrocytes in Mice. [Abstract]

2025 Jul 2;16(13):2546-2558. PMID: 40512028

ZINC00640089 purchased from MedChemExpress. Usage Cited in: ACS Chem Neurosci. 2025 Jul 2;16(13):2546-2558. [Abstract]

ZINC00640089 (ZIN; 5 mg/kg; 200 μL; IP; once per 2 days up to the 28th day) in male C57BL/6J wild-type mice (200 nL of type IV collagenase (0.05 U) was injected into the thalamus ). Thermal (50 °C) and mechanical (0.07 and 0.4 g) allodynia were detected before and after TH induction. ZIN significantly worsened TH-induced allodynia.

ZINC00640089 purchased from MedChemExpress. Usage Cited in: ACS Chem Neurosci. 2025 Jul 2;16(13):2546-2558. [Abstract]

ZINC00640089 (ZIN; 5 mg/kg; 200 μL; IP; once per 2 days up to the 28th day) in male C57BL/6J wild-type mice (200 nL of type IV collagenase (0.05 U) was injected into the thalamus). Representative images and statistical analysis of the expression of c-fos on somatosensory regions of the cortex.

ZINC00640089 purchased from MedChemExpress. Usage Cited in: ACS Chem Neurosci. 2025 Jul 2;16(13):2546-2558. [Abstract]

Effect of Oba and ZINC00640089 (LCN2 inhibitors) on the phagocytic effect of astrocytes on synapses, inflammatory responses, and ferroptosis within the thalamic region 28 days after TH. Representative images and statistical analysis of the localization of (A) MERTK and (B) Homer1 on astrocytes (GFAP). ZINC00640089 (ZIN; 5 mg/kg; 200 μL; IP; once per 2 days up to the 28th day) in male C57BL/6J wild-type mice (200 nL of type IV collagenase (0.05 U) was injected into the thalamus).
Toxicol Appl Pharmacol

LCN2-positive alveolar type II cells promote silica-induced pulmonary fibrosis via STAT3-TGF-β1-Smad3-mediated signaling. [Abstract]

2025 Sep 27:505:117579. PMID: 41022160

ZINC00640089 purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2025 Sep 27:505:117579. [Abstract]

After exposing MLE12 cells to ZINC00640089 (10 μM) for 48 h, E-cadherin and Vimentin protein expression was quantified by Western blotting.
Sci Total Environ

Neurotoxic effects of polystyrene nanoplastics on memory and microglial activation: Insights from in vivo and in vitro studies. [Abstract]

2024 May 10:924:171681. PMID: 38490422

Solvent & Solubility

In Vitro:

DMSO : 8 mg/mL (21.60 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7003 mL

13.5015 mL

27.0029 mL

5 mM

0.5401 mL

2.7003 mL

5.4006 mL

10 mM

0.2700 mL

1.3501 mL

2.7003 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Santiago-Sánchez GS, et al. Targeting Lipocalin-2 in Inflammatory Breast Cancer Cells with Small Interference RNA and Small Molecule Inhibitors. Int J Mol Sci. 2021 Aug 10;22(16):8581. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7003 mL	13.5015 mL	27.0029 mL	67.5074 mL
	5 mM	0.5401 mL	2.7003 mL	5.4006 mL	13.5015 mL
	10 mM	0.2700 mL	1.3501 mL	2.7003 mL	6.7507 mL
	15 mM	0.1800 mL	0.9001 mL	1.8002 mL	4.5005 mL
	20 mM	0.1350 mL	0.6751 mL	1.3501 mL	3.3754 mL

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ZINC00640089

Publications Citing Use of MedChemExpress (MCE) ZINC00640089

All Akt Isoforms

Biological Activity

Chemical Information

Publications (9)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

ZINC00640089 Related Classifications

HY-Q45780 Related Classifications