2. PI3K/Akt/mTOR
  3. Akt
  4. ZINC00640089

ZINC00640089 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00640089 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. ZINC00640089 has good potential for research in inflammatory breast cancer (IBC).

For research use only. We do not sell to patients.

ZINC00640089 Chemical Structure

ZINC00640089 Chemical Structure

CAS No. : 667880-11-7

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Based on 1 publication(s) in Google Scholar

ZINC00640089 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE ZINC00640089

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Akt Akt1 Akt2 Akt3

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Description

ZINC00640089 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00640089 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. ZINC00640089 has good potential for research in inflammatory breast cancer (IBC)[1].

IC50 & Target

LCN2[1].
In Vitro

ZINC00640089 (0.01-100 µM; 72 h) reduces cell proliferation and cell viability in SUM149 cells[1].
ZINC00640089 (1, 10 µM; 15 min, 1 h) reduces the p-Akt levels in SUM149 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ZINC00640089 Related Antibodies

Cell Viability Assay[1]

Cell Line: SUM149 cells
Concentration: 0.01-100 µM
Incubation Time: 72 h
Result: Reduced cell viability at concentrations of 1 µM or lower.

Western Blot Analysis[1]

Cell Line: SUM149 cells
Concentration: 1, 10 µM
Incubation Time: 15 min, 1 h, 24 h
Result: Reduced the p-Akt protein levels 15 min and 1 h and changes in the p-Akt protein levels were not observed at 24 h.
Molecular Weight

370.32

Formula

C20H13F3N2O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(CN1C(C2=C3C1=CC=CC3=CC=C2)=O)NC4=C(C(F)(F)F)C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (33.75 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7004 mL 13.5018 mL 27.0037 mL
5 mM 0.5401 mL 2.7004 mL 5.4007 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.82%

COA (256 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7004 mL 13.5018 mL 27.0037 mL 67.5092 mL
5 mM 0.5401 mL 2.7004 mL 5.4007 mL 13.5018 mL
10 mM 0.2700 mL 1.3502 mL 2.7004 mL 6.7509 mL
15 mM 0.1800 mL 0.9001 mL 1.8002 mL 4.5006 mL
20 mM 0.1350 mL 0.6751 mL 1.3502 mL 3.3755 mL
25 mM 0.1080 mL 0.5401 mL 1.0801 mL 2.7004 mL
30 mM 0.0900 mL 0.4501 mL 0.9001 mL 2.2503 mL
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ZINC00640089 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZINC00640089667880-11-7ZINC 00640089ZINC-00640089AktPKBProtein kinase BIBCinflammatory breast cancerAKTproliferationSUM149 cellInhibitorinhibitorinhibit

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