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  3. Loureirin A

Loureirin A 

Cat. No.: HY-N1505 Purity: 99.76%
Handling Instructions

Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity.

For research use only. We do not sell to patients.

Loureirin A Chemical Structure

Loureirin A Chemical Structure

CAS No. : 119425-89-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 198 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity.

IC50 & Target[1]

Akt

 

In Vitro

Loureirin A (50 μM, 100 μM) inhibits collagen-induced platelet ATP secretion and thrombin-stimulated P-selectin expression in a dose-dependent manner. Loureirin A also significantly impairs platelet spreading on immobilized fibrinogen. Loureirin A almost completely eliminates collagen-induced Akt phosphorylation at Ser473 at the dose of 100 μM, and has an additive inhibitory effect with the phosphoinositide 3-kinase (PI3K) inhibitor Ly294002 on collage-induced Akt phosphorylation in platelets at 50 μM[1].

Molecular Weight

286.32

Formula

C₁₇H₁₈O₄

CAS No.

119425-89-7

SMILES

O=C(C1=CC=C(O)C=C1)CCC2=CC=C(OC)C=C2OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 86.6 mg/mL (302.46 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4926 mL 17.4630 mL 34.9260 mL
5 mM 0.6985 mL 3.4926 mL 6.9852 mL
10 mM 0.3493 mL 1.7463 mL 3.4926 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.76%

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Keywords:

Loureirin AAktPKBProtein kinase BInhibitorinhibitorinhibit

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Loureirin A
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