2. Immunology/Inflammation NF-κB MAPK/ERK Pathway
  3. NO Synthase COX NF-κB MEK
  4. Anemarsaponin B

Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .

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Anemarsaponin B

Anemarsaponin B Chemical Structure

CAS No. : 139051-27-7

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Customer Review

Based on 1 publication(s) in Google Scholar

Anemarsaponin B Related Antibodies

Top Publications Citing Use of Products

View All NO Synthase Isoform Specific Products:

View All Isoforms
nNOS iNOS eNOS

View All COX Isoform Specific Products:

View All Isoforms
COX COX-1 COX-2 COX-3

View All NF-κB Isoform Specific Products:

View All Isoforms
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

View All MEK Isoform Specific Products:

View All Isoforms
MEK1 MEK2 MEK5 MEK MAP2K4/MEK4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect [1].

IC50 & Target[1]

COX-2

 

iNOS

 

p65

 

Molecular Weight

903.06

Formula

C45H74O18
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1C(CO)OC(OC2CCC(C(CCC3(C)C4CC5C3C(C)=C(CCC(COC6OC(CO)C(O)C(O)C6O)C)O5)C4CC7)(C)C7C2)C(OC8OC(CO)C(O)C(O)C8O)C1O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (55.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1073 mL 5.5367 mL 11.0735 mL
5 mM 0.2215 mL 1.1073 mL 2.2147 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.43%

SDS (251 KB)

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1073 mL 5.5367 mL 11.0735 mL 27.6837 mL
5 mM 0.2215 mL 1.1073 mL 2.2147 mL 5.5367 mL
10 mM 0.1107 mL 0.5537 mL 1.1073 mL 2.7684 mL
15 mM 0.0738 mL 0.3691 mL 0.7382 mL 1.8456 mL
20 mM 0.0554 mL 0.2768 mL 0.5537 mL 1.3842 mL
25 mM 0.0443 mL 0.2215 mL 0.4429 mL 1.1073 mL
30 mM 0.0369 mL 0.1846 mL 0.3691 mL 0.9228 mL
40 mM 0.0277 mL 0.1384 mL 0.2768 mL 0.6921 mL
50 mM 0.0221 mL 0.1107 mL 0.2215 mL 0.5537 mL
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Anemarsaponin B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anemarsaponin B139051-27-7NO SynthaseCOXNF-κBMEKNitric oxide synthasesNOSCyclooxygenaseNuclear factor-κBNuclear factor-kappaBMitogen-activated protein kinase kinaseMAPKKMAP2KInhibitorinhibitorinhibit

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