Cat. No.: HY-N0811

Anemarsaponin B

Customer Review

Based on 1 Customer Validation

Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .

For research use only. We do not sell to patients.

Purity: 99.43%
CAS No.: 139051-27-7
Formula: C₄₅H₇₄O₁₈
Molecular Weight:903.06

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Anemarsaponin B Chemical Structure

CAS No.: 139051-27-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

COX-2

iNOS

p65

All NO Synthase Isoforms :

All COX Isoforms :

All NF-κB Isoforms :

All MEK Isoforms :

Chemical Information

CAS No. 139051-27-7
Appearance Solid
Molecular Weight 903.06
Formula C₄₅H₇₄O₁₈
Color White to off-white
SMILES

OC1C(CO)OC(OC2CCC(C(CCC3(C)C4CC5C3C(C)=C(CCC(COC6OC(CO)C(O)C(O)C6O)C)O5)C4CC7)(C)C7C2)C(OC8OC(CO)C(O)C(O)C8O)C1O
Structure Classification
- Steroids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (55.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1073 mL

5.5367 mL

11.0735 mL

5 mM

0.2215 mL

1.1073 mL

2.2147 mL

10 mM

0.1107 mL

0.5537 mL

1.1073 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kim JY, et al. Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-kappaB and p38 pathways. Food Chem Toxicol. 2009 Jul;47(7):1610-7. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.1073 mL	5.5367 mL	11.0735 mL	27.6837 mL
	5 mM	0.2215 mL	1.1073 mL	2.2147 mL	5.5367 mL
	10 mM	0.1107 mL	0.5537 mL	1.1073 mL	2.7684 mL
	15 mM	0.0738 mL	0.3691 mL	0.7382 mL	1.8456 mL
	20 mM	0.0554 mL	0.2768 mL	0.5537 mL	1.3842 mL
	25 mM	0.0443 mL	0.2215 mL	0.4429 mL	1.1073 mL
	30 mM	0.0369 mL	0.1846 mL	0.3691 mL	0.9228 mL
	40 mM	0.0277 mL	0.1384 mL	0.2768 mL	0.6921 mL
	50 mM	0.0221 mL	0.1107 mL	0.2215 mL	0.5537 mL

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Anemarsaponin B

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

MAPK Compound Library

NF-κB Signaling Compound Library

Stem Cell Signaling Compound Library

Natural Product Library

Anti-Aging Compound Library

Antioxidant Compound Library

Differentiation Inducing Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

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Anti-Brain Cancer Compound Library

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All NO Synthase Isoforms

All COX Isoforms

All NF-κB Isoforms

All MEK Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Anemarsaponin B Related Classifications

HY-N0811 Related Classifications