2. Apoptosis
  3. TNF Receptor
  4. UTL-5g

UTL-5g (GBL-5g), an anti-inflammatory TNF-α inhibitor, has chemoprotective and liver radioprotective effects. UTL-5g lowers hepatotoxicity, nephrotoxicity, and myelotoxicity induced by Cisplatin through TNF-α inhibition among other factors.

For research use only. We do not sell to patients.

UTL-5g Chemical Structure

UTL-5g Chemical Structure

CAS No. : 646530-37-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 268 In-stock
Solution
10 mM * 1 mL in DMSO USD 268 In-stock
Solid
1 mg USD 90 In-stock
5 mg USD 220 In-stock
10 mg USD 340 In-stock
25 mg USD 680 In-stock
50 mg USD 1090 In-stock
100 mg USD 1650 In-stock
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Based on 1 publication(s) in Google Scholar

UTL-5g Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

UTL-5g (GBL-5g), an anti-inflammatory TNF-α inhibitor, has chemoprotective and liver radioprotective effects. UTL-5g lowers hepatotoxicity, nephrotoxicity, and myelotoxicity induced by Cisplatin through TNF-α inhibition among other factors[1][2].

In Vitro

RAW 264.7 macrophages are transfected with the respective reporter assay plasmids, pretreated with UTL-5g at 1, 10 or 50 µM for 60 min and then challenged with 100 ng/ml LPS. After a 16 h incubation, transcription factor activity is measured. Transcription factors that shows a UTL-5g dose-dependent decrease in activity in two experiments are categorized as being disrupted by UTL-5g.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UTL-5g Related Antibodies
In Vivo

UTL-5g (GBL-5g) lowers levels of TGF-β and TNF-α elevated by lung irradiation[1].
UTL-5g (60 mg/kg; p.o.; daily for 4 days) shows positive effects in increasing the survival rates and extending the survival times[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6, male mice (8-10 weeks)[1]
Dosage: 15, 30, and 60 mg/kg
Administration: I.p.; before irradiation, daily x 5
Result: Blood levels of TGF-β were lowered.
Animal Model: BDF1 female mice[3]
Dosage: P.o.; daily for 4 days
Administration: 60 mg/kg (30 min before i.p. injection of Cisplatin at 10, 15, and 20 mg/kg respectively on Day 0)
Result: Increased the survival rate and delayed the time to death for mice treated with 150% of the maximum tolerated dose (MTD) of Cisplatin (15 mg/kg). At 200% of the MTD of Cisplatin (20 mg/kg), treatment of UTL-5g increased the survival rate and delayed the time to death.
Molecular Weight

271.10

Formula

C11H8Cl2N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NOC(C)=C1)NC2=CC=C(Cl)C=C2Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (368.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6887 mL 18.4434 mL 36.8868 mL
5 mM 0.7377 mL 3.6887 mL 7.3774 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (9.22 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6887 mL 18.4434 mL 36.8868 mL 92.2169 mL
5 mM 0.7377 mL 3.6887 mL 7.3774 mL 18.4434 mL
10 mM 0.3689 mL 1.8443 mL 3.6887 mL 9.2217 mL
15 mM 0.2459 mL 1.2296 mL 2.4591 mL 6.1478 mL
20 mM 0.1844 mL 0.9222 mL 1.8443 mL 4.6108 mL
25 mM 0.1475 mL 0.7377 mL 1.4755 mL 3.6887 mL
30 mM 0.1230 mL 0.6148 mL 1.2296 mL 3.0739 mL
40 mM 0.0922 mL 0.4611 mL 0.9222 mL 2.3054 mL
50 mM 0.0738 mL 0.3689 mL 0.7377 mL 1.8443 mL
60 mM 0.0615 mL 0.3074 mL 0.6148 mL 1.5369 mL
80 mM 0.0461 mL 0.2305 mL 0.4611 mL 1.1527 mL
100 mM 0.0369 mL 0.1844 mL 0.3689 mL 0.9222 mL
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UTL-5g Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UTL-5g646530-37-2GBL-5gTNF ReceptorTumor Necrosis Factor ReceptorTNFRanti-inflammatorychemoprotectiveradioprotectivehepatotoxicityacutelivertoxicityInhibitorinhibitorinhibit

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