1. Apoptosis
  2. TNF Receptor
  3. UCB-9260

UCB-9260 

Cat. No.: HY-133122 Purity: 99.67%
Handling Instructions

UCB-9260, an orally active compound, inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13 nM.

For research use only. We do not sell to patients.

UCB-9260 Chemical Structure

UCB-9260 Chemical Structure

CAS No. : 1515888-53-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 330 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 500 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1050 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2550 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

UCB-9260, an orally active compound, inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13 nM[1].

In Vitro

UCB-9260 (0-10 μM) inhibits NF-κB with a geometric mean IC50 of 202 nM after TNF (10 pM) stimulation in in Hek-293 cells[1].
UCB-9260 inhibits TNF-dependent cytotoxicity with a geometric mean IC50 of 116 nM and a geometric mean IC50 of 120 nM, using human and mouse TNF, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

UCB-9260 (150 mg/kg; p.o.;twice daily for 7 days) shows a significant reduction of the clinical score[1].
UCB-9260 (10-300 mg/kg; p.o.) dose-dependently inhibits human and mouse TNF-induced neutrophil recruitment to the peritoneal compartment in adult male Balb/c mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Aged 6-8 weeks adult male Balb/c mice ( CAIA model)[1]
Dosage: 150 mg/kg
Administration: p.o.; twice daily for 7days 
Result: Showed a significant reduction of the clinical score.
Molecular Weight

423.51

Formula

C₂₆H₂₅N₅O

CAS No.

1515888-53-5

SMILES

OC(C1=CC=NC=C1)C2=NC3=CC=C(C4=CN(C)N=C4)C=C3N2CC5=CC(C)=CC=C5C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (295.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3612 mL 11.8061 mL 23.6122 mL
5 mM 0.4722 mL 2.3612 mL 4.7224 mL
10 mM 0.2361 mL 1.1806 mL 2.3612 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (14.76 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

UCB-9260UCB9260UCB 9260TNF ReceptorTumor Necrosis Factor ReceptorTNFRasymmetriccytokineautoimmunerheumatoidarthritistrimerselectivecytotoxicityneutrophilInhibitorinhibitorinhibit

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UCB-9260
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HY-133122
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