1. Apoptosis
  2. TNF Receptor
  3. UCB-9260

UCB-9260 

Cat. No.: HY-133122
Handling Instructions

UCB-9260, an orally active compound, inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13 nM.

For research use only. We do not sell to patients.

UCB-9260 Chemical Structure

UCB-9260 Chemical Structure

CAS No. : 1515888-53-5

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Description

UCB-9260, an orally active compound, inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13 nM[1].

In Vitro

UCB-9260 (0-10 μM) inhibits NF-κB with a geometric mean IC50 of 202 nM after TNF (10 pM) stimulation in in Hek-293 cells[1].
UCB-9260 inhibits TNF-dependent cytotoxicity with a geometric mean IC50 of 116 nM and a geometric mean IC50 of 120 nM, using human and mouse TNF, respectively[1].

In Vivo

UCB-9260 (150 mg/kg; p.o.;twice daily for 7 days) shows a significant reduction of the clinical score[1].
UCB-9260 (10-300 mg/kg; p.o.) dose-dependently inhibits human and mouse TNF-induced neutrophil recruitment to the peritoneal compartment in adult male Balb/c mice[1].

Animal Model: Aged 6-8 weeks adult male Balb/c mice ( CAIA model)[1]
Dosage: 150 mg/kg
Administration: p.o.; twice daily for 7days 
Result: Showed a significant reduction of the clinical score.
Molecular Weight

423.51

Formula

C₂₆H₂₅N₅O

CAS No.

1515888-53-5

SMILES

OC(C1=CC=NC=C1)C2=NC3=CC=C(C4=CN(C)N=C4)C=C3N2CC5=CC(C)=CC=C5C

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

UCB-9260UCB9260UCB 9260TNF ReceptorTumor Necrosis Factor ReceptorTNFRasymmetriccytokineautoimmunerheumatoidarthritistrimerselectivecytotoxicityneutrophilInhibitorinhibitorinhibit

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UCB-9260
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