1. Apoptosis
  2. TNF Receptor

SPD304 

Cat. No.: HY-111255 Purity: >99.0%
Handling Instructions

SPD304 is a selective inhibitor of tumor necrosis factor α (TNFα) and promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor, with an IC50 of 22 µM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α. SPD304 cannot be used in vivo due to its high toxicity.

For research use only. We do not sell to patients.

SPD304 Chemical Structure

SPD304 Chemical Structure

CAS No. : 869998-49-2

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

SPD304 is a selective inhibitor of tumor necrosis factor α (TNFα) and promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor, with an IC50 of 22 µM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α[1][2]. SPD304 cannot be used in vivo due to its high toxicity[3].

IC50 & Target

IC50: 22 µM (TNFα)[1].

In Vitro

SPD304 (2 μM) significantly rescues the survivability of aHSCs, reduces the production of lipid hydroxides, and increased intracellular GSH. The co-treatment of GA (75 μM) and SPD304 (2 μM), down-regulate TRADD almost 2-fold (w/o inhibitor vs. w/ inhibitor) and p−RIP3 1.4−fold compared to GA alone, and promotes caspase 8 activation[4].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8261 mL 9.1306 mL 18.2612 mL
5 mM 0.3652 mL 1.8261 mL 3.6522 mL
10 mM 0.1826 mL 0.9131 mL 1.8261 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

547.61

Formula

C₃₂H₃₂F₃N₃O₂

CAS No.

869998-49-2

SMILES

O=C1C(CN(C)CCN(C)CC2=CN(C3=CC=CC(C(F)(F)F)=C3)C4=C2C=CC=C4)=COC5=CC(C)=C(C)C=C15

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >99.0%

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Product Name:
SPD304
Cat. No.:
HY-111255
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SPD304

Cat. No.: HY-111255