1. Apoptosis
  2. TNF Receptor

Bioymifi (Synonyms: DR5 Activator)

Cat. No.: HY-18377 Purity: >98.0%
Handling Instructions

Bioymifi(DR5 Activator) is the first novel and potent small-molecule activatior of the TRAIL receptor DR5 in human cancer cells.

For research use only. We do not sell to patients.

Bioymifi Chemical Structure

Bioymifi Chemical Structure

CAS No. : 1420071-30-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 86 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 78 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 126 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
25 mg USD 252 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 456 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg USD 804 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Bioymifi(DR5 Activator) is the first novel and potent small-molecule activatior of the TRAIL receptor DR5 in human cancer cells. IC50 value: Target: In comparison with A2C2, bioymifi was able to promote cell death without the need for the Smac mimetic in T98G cells. Notably, at a 10-μM concentration, bioymifi induced processing of caspase-3 into smaller fragments. Z-VAD inhibited these caspase-mediated cleavages. caspase-3 was rapidly activated as early as 2 h after bioymifi treatment of T98G cells. The caspase-3 activity was markedly increased after 8 h of treatment. Bioymifi induces caspase-8–dependent apoptosis.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.0230 mL 10.1149 mL 20.2298 mL
5 mM 0.4046 mL 2.0230 mL 4.0460 mL
10 mM 0.2023 mL 1.0115 mL 2.0230 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

494.32

Formula

C₂₂H₁₂BrN₃O₄S

CAS No.

1420071-30-2

SMILES

O=C(/C(SC1=N)=C/C2=CC=C(O2)C3=CC(C(N4)=O)=C(C=C3)C4=O)N1C5=CC=C(C=C5)Br

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 23.5 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Bioymifi
Cat. No.:
HY-18377
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