646530-37-2
646530-37-2
Chemical Structure
UTL-5g
Synonym(s): GBL-5g
- CAS No.: 646530-37-2
- Formula:C11H8Cl2N2O2
- Molecular Weight:271.10
IUPAC Name: N-(2,4-dichlorophenyl)-5-methylisoxazole-3-carboxamide
InChIKey: ULPKSWAQDCJLMN-UHFFFAOYSA-N
SMILES: O=C(C1=NOC(C)=C1)NC2=CC=C(Cl)C=C2Cl
Biological Activity: UTL-5g (GBL-5g), an anti-inflammatory TNF-α inhibitor, has chemoprotective and liver radioprotective effects. UTL-5g lowers hepatotoxicity, nephrotoxicity, and myelotoxicity induced by Cisplatin through TNF-α inhibition among other factors[1][2].
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UTL-5g | 99.92% | UTL-5g (GBL-5g), an anti-inflammatory TNF-α inhibitor, has chemoprotective and liver radioprotective effects. UTL-5g lowers hepatotoxicity, nephrotoxicity, and myelotoxicity induced by Cisplatin through TNF-α inhibition among other factors. | ||||||||||||||||||||
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References
- [1]. Stephen Brown, et al. UTL-5g Lowers Levels of TGF-β and TNF-α Elevated by Lung Irradiation
- [2]. Carruthers NJ, et al. Phosphoproteome and transcription factor activity profiling identify actions of the anti-inflammatory agent UTL-5g in LPS stimulated RAW 264.7 cells including disrupting actin remodeling and STAT-3 activation. Eur J Pharmacol. 2017;811:66-73. [Content Brief]
