1. Apoptosis
  2. TNF Receptor
  3. Geraniin

Geraniin 

Cat. No.: HY-N0472 Purity: 99.10%
Handling Instructions

Geraniin is a TNF-α releasing inhibitor with numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities, with an IC50 of 43 μM.

For research use only. We do not sell to patients.

Geraniin Chemical Structure

Geraniin Chemical Structure

CAS No. : 60976-49-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 157 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Geraniin is a TNF-α releasing inhibitor with numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities, with an IC50 of 43 μM.

IC50 & Target

IC50: 43 μM (TNF-α)[1].

In Vitro

The IC50 value of TNF-α release inhibition is 43 μM for Geraniin[1]. Geraniin has long been used as a medicinal herb and possesses numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities. Geraniin significantly decreases the viability of OVCAR3 and SKOV3 cells in a concentration-dependent fashion. The IC50 value for Geraniin treatment is 34.5±2.8 μM in OVCAR3 cells and 23.6±1.9 μM in SKOV3 cells. However, Geraniin up to the maximal concentration used (80 μM) has no significant impact on the viability of normal human ovarian surface epithelial cells. Treatment with 10 and 40 μM of Geraniin for 48 h causes a significant increase in apoptosis (16.8±1.2% and 22.6±1.4%, respectively), compared with control OVCAR3 cells (3.9±1.1%). Similar results are observed in SKOV3 cells[2].

In Vivo

Treatment with Geraniin prior to application of okadaic acid delays development of tumors compared with control group, reduces the percentage of tumor bearing mice from 80.0% to 40.0%, and reduces the average numbers of tumor per mouse from 3.8 to 1.1 in week 20. It is also showed that oral administration of Geraniin to rats (50 mg/kg/d or 100 mg/kg/d) inhibit the elevation of serum total cholesterol, lipid peroxide, free fatty acid, triglyceride, glutamic oxaloacetic transaminase and glutamic pyruvic transaminase induced by treatment with peroxidized oil[1].

Molecular Weight

952.64

Formula

C₄₁H₂₈O₂₇

CAS No.

60976-49-0

SMILES

O=C(OC[[email protected]](O[[email protected]@H](OC(C1=CC(O)=C(O)C(O)=C1)=O)[[email protected]]2OC3=O)[[email protected]](OC(C(C4C5=C3C=C(O)C(O)=C5OC6(O)C4(O)O)=CC6=O)=O)[[email protected]]2O7)C8=CC(O)=C(O)C(O)=C8C9=C(O)C(O)=C(O)C=C9C7=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (104.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0497 mL 5.2486 mL 10.4971 mL
5 mM 0.2099 mL 1.0497 mL 2.0994 mL
10 mM 0.1050 mL 0.5249 mL 1.0497 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.62 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.62 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[2]

Human ovarian cancer cell lines OVCAR3 and SKOV3 are used. Cells are exposed to different concentrations (5, 10, 20, 40, and 80 μM) of Geraniin for 48 h and examined for viability, apoptosis, and gene expression. The concentration range is selected based on previous studies[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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