1. Metabolic Enzyme/Protease
    NF-κB
    Immunology/Inflammation
  2. HIF/HIF Prolyl-Hydroxylase
    Reactive Oxygen Species
  3. Moracin O

Moracin O 

Cat. No.: HY-N3244
Handling Instructions

Moracin O is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin O exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin O reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin O has neuroprotective and anti-inflammatory effects.

For research use only. We do not sell to patients.

Moracin O Chemical Structure

Moracin O Chemical Structure

CAS No. : 123702-97-6

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Description

Moracin O is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin O exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin O reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin O has neuroprotective and anti-inflammatory effects[1][2][3].

In Vitro

Moracin O enhances cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells with an EC50 value of 12.6 μM. Moracin O reduces ROS production in OGD-induced cell death (IC50 value of 0.3 μM). Moracin O protects neuronal cell death against the oxidative stress induced by OGD[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

326.34

Formula

C₁₉H₁₈O₅

CAS No.
SMILES

CC(O)([[email protected]]1CC2=CC(C=C(C3=CC(O)=CC(O)=C3)O4)=C4C=C2O1)C

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Moracin OHIF/HIF Prolyl-HydroxylaseReactive Oxygen SpeciesHypoxia-inducible factorsHIFsHIF-PHHIF-12-arylbenzofuranneuroprotectiveanti-inflammatoryROSInhibitorinhibitorinhibit

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Moracin O
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HY-N3244
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