2. Apoptosis NF-κB
  3. NF-κB Apoptosis
  4. 15-Deoxy-Δ12,14-prostaglandin A1

15-Deoxy-Δ12,14-prostaglandin A1 is a deoxyanalog of prostaglandins that inhibits NF-κB signaling and induces apoptosis. 15-Deoxy-Δ12,14-prostaglandin A1 inhibits TNF-α-induced upregulation of inflammatory endothelial cell adhesion molecule (CAM) and avoids monocyte arrest.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

15-Deoxy-Δ12,14-prostaglandin A1

15-Deoxy-Δ12,14-prostaglandin A1 화학구조

CAS No. : 573951-20-9

사이즈 가격 재고 수량
500 μg 견적 받기 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks
1 mg 견적 받기 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks
5 mg   견적 받기  
10 mg   견적 받기  
Synthetic products have potential research and development risk.

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

15-Deoxy-Δ12,14-prostaglandin A1 Related Antibodies

Top Publications Citing Use of Products

View All NF-κB Isoform Specific Products:

View All Isoforms
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

15-Deoxy-Δ12,14-prostaglandin A1 is a deoxyanalog of prostaglandins that inhibits NF-κB signaling and induces apoptosis. 15-Deoxy-Δ12,14-prostaglandin A1 inhibits TNF-α-induced upregulation of inflammatory endothelial cell adhesion molecule (CAM) and avoids monocyte arrest[1].

In Vitro

15-Deoxy-Δ12,14-prostaglandin A1 (25, 50 μM; 2 h) inhibits TNF-α-induced IκB-α kinase (IKK) activation, IκB-α degradation, and NF-κB/p65 translocation while promoting AP -1/c-Jun phosphorylation [1].
15-Deoxy-Δ12,14-prostaglandin A1 (25 μM; 2 h) enhances TNF-α-induced cell death in HAEC and HUVEC [1].
15-Deoxy-Δ12,14-prostaglandin A1 (10 μM; 2 h) inhibits TNF-α-induced monocyte arrest [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

15-Deoxy-Δ12,14-prostaglandin A1 Related Antibodies

Cell Viability Assay[1]

Cell Line: HAEC and HUVEC
Concentration: 6.5, 12.5, 25 μM
Incubation Time: 2 h
Result: Markedly enhanced cell death induced by TNF-α.

Western Blot Analysis[1]

Cell Line: HAEC and HUVEC
Concentration: 25 and 50 μM
Incubation Time: 2 h
Result: Prevented the TNF-α induced inhibition of IKK, the IκB-α degradation at 25 or 50 µM but not at 6.25 or 12.5 µM.
분자량

318.45

화학식

C20H30O3
CAS No.
SMILES

OC(CCCCCC[C@@H]1/C(C=CC1=O)=C\C=C\CCCCC)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

15-Deoxy-Δ12,14-prostaglandin A1 Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

15-Deoxy-Δ12,14-prostaglandin A1573951-20-9NF-κBApoptosisNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

최근 본 상품:

온라인 문의

Your information is safe with us. * Required Fields.

상품명

  

Requested Quantity *

고객명 *

 

호칭

메일주소 *

 

전화번호 *

Department

 

회사명 *

City

도

Country or Region *

      

비고

대량구매 문의

Inquiry Information

상품명:
15-Deoxy-Δ12,14-prostaglandin A1
Cat. No.:
HY-118101
수량:
MCE Japan Authorized Agent:

고객리뷰

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

상품명

  

Lot #

고객명 *

 

메일주소 *

전화번호

 

Department *

회사명 *

 

Country or Region *

비고

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.