2. Apoptosis NF-κB
  3. NF-κB Apoptosis
  4. 15-Deoxy-Δ12,14-prostaglandin A1

15-Deoxy-Δ12,14-prostaglandin A1 is a deoxyanalog of prostaglandins that inhibits NF-κB signaling and induces apoptosis. 15-Deoxy-Δ12,14-prostaglandin A1 inhibits TNF-α-induced upregulation of inflammatory endothelial cell adhesion molecule (CAM) and avoids monocyte arrest.

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15-Deoxy-Δ12,14-prostaglandin A1 Chemical Structure

15-Deoxy-Δ12,14-prostaglandin A1 Chemical Structure

CAS No. : 573951-20-9

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15-Deoxy-Δ12,14-prostaglandin A1 Related Antibodies

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Description

15-Deoxy-Δ12,14-prostaglandin A1 is a deoxyanalog of prostaglandins that inhibits NF-κB signaling and induces apoptosis. 15-Deoxy-Δ12,14-prostaglandin A1 inhibits TNF-α-induced upregulation of inflammatory endothelial cell adhesion molecule (CAM) and avoids monocyte arrest[1].

In Vitro

15-Deoxy-Δ12,14-prostaglandin A1 (25, 50 μM; 2 h) inhibits TNF-α-induced IκB-α kinase (IKK) activation, IκB-α degradation, and NF-κB/p65 translocation while promoting AP -1/c-Jun phosphorylation [1].
15-Deoxy-Δ12,14-prostaglandin A1 (25 μM; 2 h) enhances TNF-α-induced cell death in HAEC and HUVEC [1].
15-Deoxy-Δ12,14-prostaglandin A1 (10 μM; 2 h) inhibits TNF-α-induced monocyte arrest [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

15-Deoxy-Δ12,14-prostaglandin A1 Related Antibodies

Cell Viability Assay[1]

Cell Line: HAEC and HUVEC
Concentration: 6.5, 12.5, 25 μM
Incubation Time: 2 h
Result: Markedly enhanced cell death induced by TNF-α.

Western Blot Analysis[1]

Cell Line: HAEC and HUVEC
Concentration: 25 and 50 μM
Incubation Time: 2 h
Result: Prevented the TNF-α induced inhibition of IKK, the IκB-α degradation at 25 or 50 µM but not at 6.25 or 12.5 µM.
Molecular Weight

318.45

Formula

C20H30O3
CAS No.
SMILES

OC(CCCCCC[C@@H]1/C(C=CC1=O)=C\C=C\CCCCC)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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15-Deoxy-Δ12,14-prostaglandin A1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

15-Deoxy-Δ12,14-prostaglandin A1573951-20-9NF-κBApoptosisNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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