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MAGL-IN-12

SAR127303 is an orally active, selective, competitive monoacylglycerol lipase (MAGL) covalent inhibitor with IC50s of 3.8 nM and 29 nM for mouse and human MAGL, respectively. SAR127303 potently elevates hippocampal levels of 2-AG in mice. SAR127303 decreased long term potentiation (LTP) of CA1 synaptic transmission and acetylcholine release in the hippocampus. SAR127303 produces antinociceptive effects in assays of inflammatory and visceral pain. SAR127303 slows down epileptogenesis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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  • CAS 番号: 1352011-38-1
  • 分子式: C16H17ClF6N2O4S
  • 分子量:482.83
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • MAGL-IN-12 Chemical Structure
    MAGL-IN-12 構造式
CAS 番号: 1352011-38-1
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  • MAGL-IN-12 Chemical Structure
    MAGL-IN-12 Chemical Structure
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  • MAGL-IN-12