MAGL-IN-12
SAR127303 is an orally active, selective, competitive monoacylglycerol lipase (MAGL) covalent inhibitor with IC50s of 3.8 nM and 29 nM for mouse and human MAGL, respectively. SAR127303 potently elevates hippocampal levels of 2-AG in mice. SAR127303 decreased long term potentiation (LTP) of CA1 synaptic transmission and acetylcholine release in the hippocampus. SAR127303 produces antinociceptive effects in assays of inflammatory and visceral pain. SAR127303 slows down epileptogenesis.
For research use only. We do not sell to patients.
- CAS No.: 1352011-38-1
- Formula: C16H17ClF6N2O4S
- Molecular Weight:482.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 1352011-38-1
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Molecular Weight 482.83
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Formula C16H17ClF6N2O4S
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SMILES
ClC1=CC=C(C=C1)S(NCC2CCN(CC2)C(OC(C(F)(F)F)C(F)(F)F)=O)(=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MAGL-IN-12 Related Classifications
HY-116143 Related Classifications
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