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Tesnatilimab

(Synonyms: JNJ-64304500; IPH-2301; NN-8555)
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Tesnatilimab (JNJ-64304500) is a human IgG4 monoclonal antibody targeting NKG2D, with a KD value of 9.2 pM. Tesnatilimab blocks the binding of ligands to the NKG2D receptor, thereby inhibiting downstream proinflammatory cytokine, cytotoxic mediator signaling pathways and proinflammatory immune responses. Tesnatilimab is applicable to research related to Crohn's disease.

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  • Pureté: 99.80%
  • CAS No.: 2242758-08-1
  • Masse moléculaire:143.9 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Tesnatilimab
  • Experimental Validation Results for Tesnatilimab
  • Experimental Validation Results for Tesnatilimab
  • Tesnatilimab Chemical Structure
    Tesnatilimab Chemical Structure
CAS No.: 2242758-08-1
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Flow Cytometry analysis of Ramos cells labelling CD314 (red) with Tesnatilimab (HY-P99389). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized NKG2D/CD314 Protein, Human can bind Tesnatilimab. The EC50 for this effect is 16.41 ng/mL.

  • Tesnatilimab Chemical Structure
    1/16
  • Tesnatilimab
  • Flow Cytometry analysis of Ramos cells labelling CD314 (red) with Tesnatilimab (HY-P99389). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized NKG2D/CD314 Protein, Human can bind Tesnatilimab. The EC50 for this effect is 16.41 ng/mL.