1. Cell Cycle/DNA Damage
    NF-κB
    Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. PPAR
    NF-κB
    Calcium Channel
  3. Ophiopogonin D

Ophiopogonin D 

Cat. No.: HY-N0515
Handling Instructions

Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years.

For research use only. We do not sell to patients.

Ophiopogonin D Chemical Structure

Ophiopogonin D Chemical Structure

CAS No. : 945619-74-9

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Description

Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside[1]. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years[2].

IC50 & Target

PPARα

 

NF-κB

 

Ca2+

 

Molecular Weight

855.02

Formula

C₄₄H₇₀O₁₆

CAS No.

945619-74-9

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