1. Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
    Vitamin D Related/Nuclear Receptor
    Apoptosis
  2. Cytochrome P450
    PPAR
    Apoptosis
  3. Oleuropein

Oleuropein 

Cat. No.: HY-N0292 Purity: 99.05%
COA Handling Instructions

Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase.

For research use only. We do not sell to patients.

Oleuropein Chemical Structure

Oleuropein Chemical Structure

CAS No. : 32619-42-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 61 In-stock
Solid
5 mg USD 55 In-stock
10 mg USD 88 In-stock
25 mg USD 170 In-stock
50 mg USD 260 In-stock
100 mg USD 390 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Oleuropein

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity[1]. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase[2].

IC50 & Target

PPARγ

 

Aromatase

 

Apoptosis

 

In Vitro

Aromatase, a cytochrome P450 enzyme, is an important pharmacological target in breast cancer therapy[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

540.51

Appearance

Solid

Formula

C25H32O13

CAS No.
SMILES

OC[[email protected]@H]1[[email protected]@H](O)[[email protected]](O)[[email protected]@H](O)[[email protected]@](O[[email protected]@H]2OC=C(C(OC)=O)[[email protected]@H](CC(OCCC3=CC=C(O)C(O)=C3)=O)/C2=C\C)([H])O1

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (462.53 mM; Need ultrasonic)

H2O : ≥ 20 mg/mL (37.00 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8501 mL 9.2505 mL 18.5010 mL
5 mM 0.3700 mL 1.8501 mL 3.7002 mL
10 mM 0.1850 mL 0.9251 mL 1.8501 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.05%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Oleuropein
Cat. No.:
HY-N0292
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