1. Cell Cycle/DNA Damage
    Apoptosis
    Others
  2. PPAR
    Apoptosis
    Aromatase
  3. Oleuropein

Oleuropein 

Cat. No.: HY-N0292 Purity: 98.54%
Handling Instructions

Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase.

For research use only. We do not sell to patients.

Oleuropein Chemical Structure

Oleuropein Chemical Structure

CAS No. : 32619-42-4

Size Price Stock Quantity
5 mg USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 88 In-stock
Estimated Time of Arrival: December 31
20 mg USD 154 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity[1]. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase[2].

IC50 & Target

PPARγ

 

Apoptosis

 

Aromatase

 

In Vitro

Aromatase, a cytochrome P450 enzyme, is an important pharmacological target in breast cancer therapy[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

540.51

Formula

C25H32O13

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (462.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8501 mL 9.2505 mL 18.5010 mL
5 mM 0.3700 mL 1.8501 mL 3.7002 mL
10 mM 0.1850 mL 0.9251 mL 1.8501 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
Oleuropein
Cat. No.:
HY-N0292
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