Oleuropein 

Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity^[1]. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase^[2].

Aromatase, a cytochrome P450 enzyme, is an important pharmacological target in breast cancer therapy^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

540.51

Solid

C₂₅H₃₂O₁₃

32619-42-4

OC[[email protected]@H]1[[email protected]@H](O)[[email protected]](O)[[email protected]@H](O)[[email protected]@](O[[email protected]@H]2OC=C(C(OC)=O)[[email protected]@H](CC(OCCC3=CC=C(O)C(O)=C3)=O)/C2=C\C)([H])O1

Room temperature in continental US; may vary elsewhere.

• [1]. Svobodova M, et al. Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma. Genes Nutr. 2014 Jan;9(1):376.  [Content Brief]

  [2]. Gorzynik-Debicka M, et al. Potential Health Benefits of Olive Oil and Plant Polyphenols. Int J Mol Sci. 2018 Feb 28;19(3). pii: E686.  [Content Brief]