Oleuropein
Based on 10 publication(s) in Google Scholar
Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 32619-42-4
- Formula: C25H32O13
- Molecular Weight:540.51
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Publications Citing Use of MedChemExpress (MCE) Oleuropein
More- Nat Commun. 2024 Feb 5;15(1):1087. [Abstract]
- Acta Pharm Sin B. 2025 Sep;15(9):4711-4729. [Abstract]
- Phytomedicine. 2025 Dec 24:150:157740. [Abstract]
- Phytomedicine. 2025 Dec:149:157488. [Abstract]
- Cell Mol Life Sci. 2025 Nov 27;83(1):19. [Abstract]
- Cancer Gene Ther. 2025 Jul;32(7):793-805. [Abstract]
- Biomolecules. 2025 Mar 27;15(4):492. [Abstract]
- Theriogenology. 2026 May:256:117873. [Abstract]
- Tissue Cell. 2022 Oct:78:101876. [Abstract]
- Nutraceuticals. 2026 Jun;6(2):24.
Customer Validation & Images
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Cell Imaging/Staining
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In Vivo Imaging
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Bio/Physico-chemical Assay
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2D/3D Cell Culture and Differentiation
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In Vivo Efficacy Study
Biological Activity
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PPARγ |
Aromatase |
Apoptosis |
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Cell Line
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Type | Value | Description | References |
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| B16-F1 | IC50 |
283.9 μM
Compound: 1
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Antiproliferative activity against mouse B16-F1 cells after 72 hrs by MTT reduction assay
Antiproliferative activity against mouse B16-F1 cells after 72 hrs by MTT reduction assay
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[PMID: 28551177] |
| HCT-116 | IC50 |
181.86 μM
Compound: 1
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Antiproliferative activity against human HCT116 cells after 72 hrs by MTT reduction assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT reduction assay
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[PMID: 28551177] |
| HeLa | IC50 |
265.28 μM
Compound: 1
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Antiproliferative activity against human HeLa cells after 72 hrs by MTT reduction assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT reduction assay
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[PMID: 28551177] |
| HL-60 | IC50 |
54.26 μM
Compound: 1
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Antiproliferative activity against human HL60 cells after 72 hrs by MTT reduction assay
Antiproliferative activity against human HL60 cells after 72 hrs by MTT reduction assay
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[PMID: 28551177] |
| K562 | IC50 |
64.73 μM
Compound: 1
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Antiproliferative activity against human K562 cells after 72 hrs by MTT reduction assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT reduction assay
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[PMID: 28551177] |
| MCF7 | IC50 |
161.57 μM
Compound: 1
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Antiproliferative activity against human MCF7 cells after 72 hrs by MTT reduction assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT reduction assay
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[PMID: 28551177] |
| RAW264.7 | IC50 |
>80 μM
Compound: 11
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Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess reagent-based assay
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess reagent-based assay
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[PMID: 32936639] |
| SK-BR-3 | IC50 |
160.44 μM
Compound: 1
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Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT reduction assay
Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT reduction assay
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[PMID: 28551177] |
Aromatase, a cytochrome P450 enzyme, is an important pharmacological target in breast cancer therapy[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 32619-42-4
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Appearance Solid
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Molecular Weight 540.51
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Formula C25H32O13
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Color White to light yellow
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SMILES
OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@](O[C@@H]2OC=C(C(OC)=O)[C@@H](CC(OCCC3=CC=C(O)C(O)=C3)=O)/C2=C\C)([H])O1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (10)
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Journal Impact Factor
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Most Recent
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Nat Commun
2024 Feb 5;15(1):1087. PMID: 38316790
Oleuropein purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Feb 5;15(1):1087. [Abstract]
IHC experiment detecting OCT4 expression in vehicle- or Oleuropein (0.5 μg/mL)-treated WT and aneuploid primary teratomas.
Oleuropein purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Feb 5;15(1):1087. [Abstract]
BLI imaging of distant organs from teratoma-bearing mice of different aneuploidy exposure to proteasome activator Oleuropein (20 mg/kg/day, i.p.).
Oleuropein purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Feb 5;15(1):1087. [Abstract]
Oleuropein (0.5 μg/mL) treatment could increase the proteasome activity in aneuploid cells to some extent.
Oleuropein purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Feb 5;15(1):1087. [Abstract]
In vitro EB differentiation of WT and aneuploid ESCs with or without Oleuropein (0.5 μg/mL) treatment.
Oleuropein purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Feb 5;15(1):1087. [Abstract]
Treatment with Oleuropein (20 mg/kg/day, i.p.) effectively reduced aneuploid teratoma volume.
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Acta Pharm Sin B
Evidence that metformin promotes fibrosis resolution via activating alveolar epithelial stem cells and FGFR2b signaling. [Abstract]2025 Sep;15(9):4711-4729. PMID: 41049730 -
Phytomedicine
Bruceantin inhibits the c-Myc/RL27A axis to suppress tumor progression in hepatocellular carcinoma. [Abstract]2025 Dec 24:150:157740. PMID: 41477978 -
Phytomedicine
Daidzein reprograms EP300/CREBBP-deficient immune evasion via targeting the PPARγ-ANGPT4/Tie2 axis in hypopharyngeal squamous cell carcinoma. [Abstract]2025 Dec:149:157488. PMID: 41240538 -
Cell Mol Life Sci
IL-38 attenuates vascular calcification by upregulating GPX3-mediated antioxidant defense via the PPAR-γ/NRF2 axis. [Abstract]2025 Nov 27;83(1):19. PMID: 41307654 -
Cancer Gene Ther
Oleuropein regulates ubiquitination-mediated Mcl-1 turnover and exhibits antitumor activity. [Abstract]2025 Jul;32(7):793-805. PMID: 40506561 -
Biomolecules
PPARs Activity Affects the Hatchability Through Lipid Metabolism Regulation in Silkworm, Bombyx mori L. [Abstract]2025 Mar 27;15(4):492. PMID: 40305260 -
Theriogenology
Oleuropein restores oocyte competence during SIRT1 inhibition via SIRT1/NRF2-mediated redox and metabolic reprogramming in porcine oocytes. [Abstract]2026 May:256:117873. PMID: 41698313 -
Tissue Cell
Oleuropein attenuates testicular ischemia-reperfusion by inhibiting apoptosis and inflammation. [Abstract]2022 Oct:78:101876. PMID: 35914339 -
Solvent & Solubility
DMSO : 125 mg/mL (231.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 20 mg/mL (37.00 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Svobodova M, et al. Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma. Genes Nutr. 2014 Jan;9(1):376. [Content Brief]
[2]. Gorzynik-Debicka M, et al. Potential Health Benefits of Olive Oil and Plant Polyphenols. Int J Mol Sci. 2018 Feb 28;19(3). pii: E686. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.8501 mL | 9.2505 mL | 18.5010 mL | 46.2526 mL |
| 5 mM | 0.3700 mL | 1.8501 mL | 3.7002 mL | 9.2505 mL | |
| 10 mM | 0.1850 mL | 0.9251 mL | 1.8501 mL | 4.6253 mL | |
| 15 mM | 0.1233 mL | 0.6167 mL | 1.2334 mL | 3.0835 mL | |
| 20 mM | 0.0925 mL | 0.4625 mL | 0.9251 mL | 2.3126 mL | |
| 25 mM | 0.0740 mL | 0.3700 mL | 0.7400 mL | 1.8501 mL | |
| 30 mM | 0.0617 mL | 0.3084 mL | 0.6167 mL | 1.5418 mL | |
| DMSO | 40 mM | 0.0463 mL | 0.2313 mL | 0.4625 mL | 1.1563 mL |
| 50 mM | 0.0370 mL | 0.1850 mL | 0.3700 mL | 0.9251 mL | |
| 60 mM | 0.0308 mL | 0.1542 mL | 0.3084 mL | 0.7709 mL | |
| 80 mM | 0.0231 mL | 0.1156 mL | 0.2313 mL | 0.5782 mL | |
| 100 mM | 0.0185 mL | 0.0925 mL | 0.1850 mL | 0.4625 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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