1. Cell Cycle/DNA Damage
    Apoptosis
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  2. PPAR
    Apoptosis
    Aromatase
  3. Oleuropein

Oleuropein 

Cat. No.: HY-N0292 Purity: 98.54%
Handling Instructions

Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase.

For research use only. We do not sell to patients.

Oleuropein Chemical Structure

Oleuropein Chemical Structure

CAS No. : 32619-42-4

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5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
20 mg USD 140 In-stock
Estimated Time of Arrival: December 31
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Description

Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity[1]. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase[2].

IC50 & Target

PPARγ

 

Apoptosis

 

Aromatase

 

In Vitro

Aromatase, a cytochrome P450 enzyme, is an important pharmacological target in breast cancer therapy[2].

Molecular Weight

540.51

Formula

C₂₅H₃₂O₁₃

CAS No.

32619-42-4

SMILES

OC[[email protected]@H]1[[email protected]@H](O)[[email protected]](O)[[email protected]@H](O)[[email protected]@](O[[email protected]@H]2OC=C(C(OC)=O)[[email protected]@H](CC(OCCC3=CC=C(O)C(O)=C3)=O)/C2=C\C)([H])O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (462.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8501 mL 9.2505 mL 18.5010 mL
5 mM 0.3700 mL 1.8501 mL 3.7002 mL
10 mM 0.1850 mL 0.9251 mL 1.8501 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

OleuropeinPPARApoptosisAromatasePeroxisome proliferator-activated receptorsoliveleavesoilantioxidantanti-inflammatoryanti-atherogenicPPARγapoptosisbreastcanceraromataseInhibitorinhibitorinhibit

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Oleuropein
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HY-N0292
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