Chloranthaceae
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- Sarcandra glabra (Thunb.) Nakai (10)
- Chloranthus erectus (Buchanan-Hamilton) Verdcourt (8)
- Chloranthus serratus (Thunb.) Roem. et Schult. (8)
- Chloranthus spicatus (Thunb.) Makino (8)
- Chloranthus japonicus Sieb. (4)
- Chloranthus fortunei (A. Gray) Solms-Laub (2)
- Chloranthus henryi Hemsl. (2)
- Chloranthus holostegius (Hand.-Mazz.) Pei et Shan (2)
- Chloranthus anhuiensis K. F. Wu (1)
- Chloranthus serratus var. taiwanensis K. F. Wu (1)
- Hedyosmum brasiliense Mart. (1)
- Sarcandra glabra subsp. brachystachys (Blume) Verdcourt (1)
- Formula: C40H44O13
- Molecular Weight: 732.77
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression.
- Formula: C31H34O6
- Molecular Weight: 502.60
Shizukaol A is an sesquiterpene dimer that can be isolated from Chloranthus japonicas.
- Formula: C17H18O4
- Molecular Weight: 286.32
Chlojaponilactone B is a lindenane-type sesquiterpenoid with anti-inflammatory properties. Chlojaponilactone B suppresses inflammatory responses by inhibiting TLR4 and subsequently decreasing reactive oxygen species (ROS) generation, downregulating the NF-κB, thus reducing the expression of the pro-inflammatory cytokines iNOS, NO, COX-2, IL-6 and TNF-α.
- Formula: C15H16O3
- Molecular Weight: 244.29
- Formula: C39H42O14
- Molecular Weight: 734.74
Chloramultilide B is a lindenane dimer that can be isolated from Chloranthus serratus. Chloramultilide B has inhibitory activities against Candida albicans and C.parapsilosis with a MIC value of 0.068 μM.
- Formula: C17H16O4
- Molecular Weight: 284.31
(E/Z)-Flavokawain B (compound 4) is a chalcone and nitric oxide production inhibitor with an IC50 of 6.8 μM.(E/Z)-Flavokawain B can be found in the aerial parts of Sarcandra glabra.(E/Z)-Flavokawain B inhibits lipopolysaccharide-induced nitric oxide production.
- Formula: C15H20O3
- Molecular Weight: 248.32
Shizukolidol is an antimicrobial agent that can be isolated from polyfollicles of Magnolia vovidessi. Shizukolidol shows antibacterial activity against Chryseobacterium sp. Shizukolidol can be used for the research of bacterial infection.
- Formula: C27H32O5
- Molecular Weight: 436.54
Glabralide A is a natural chalcone.
- Formula: C33H36O9
- Molecular Weight: 576.63
Chlorahololide C, a lindenane sesquiterpenoid dimer, is isolated from Chloranthus holostegius. Chlorahololide C is a potent and selective potassium channel blocker, with an IC50 of 3.6 μM.
- Formula: C21H26O3
- Molecular Weight: 326.43
Glabralide B is a natural phenolic compound.
- Formula: C17H20O4
- Molecular Weight: 288.34
Chloranthalactone C (Compound 43), a lindenane-type sesquiterpenoid, is an antimalarial agent. Chloranthalactone C can be isolated from plant Chloranthus japonicas Sieb. Chloranthalactone C inhibits Chloroquine (HY-17589A)-resistant Plasmodium falciparum strain Dd2 growth. Chloranthalactone C can be used for parasitic infections research.
- Formula: C15H18O3
- Molecular Weight: 246.30
Chlorantholide C, an eudesmane-type sesquiterpene lactone, can be isolated from Chloranthus elatior.
- Formula: C33H38O9
- Molecular Weight: 578.65
- Formula: C38H44O12
- Molecular Weight: 692.75
Sarglaroids F (compound 6) is an anti-inflammatory agent isolated from the roots of Grass Coral. Sarglaroids F inhibits LPS/ATP-induced IL-1β release by affecting K+ efflux and reducing Caspase-1(P20) levels. Sarglaroids F is not cytotoxic to RAW264.7 cells.
- Formula: C15H26O2
- Molecular Weight: 238.37
Aromadendrane-4β,10α-diol is a sesquiterpene alcohol. Aromadendrane-4β,10α-diol significantly ameliorates the Aβ1-42 peptide-induced memory impairment. Aromadendrane-4β,10α-diol can be used for Alzheimer's disease (AD) research.
- Formula: C32H36O8
- Molecular Weight: 548.62
Cycloshizukaol A is a symmetrical cyclic lindenane dimer with C2 symmetry. Cycloshizukaol A can be isolated from the root of Chloranthus serratus.
- Formula: C29H40O4
- Molecular Weight: 452.63
Glabralide C is a meroterpenoid. Glabralide C can be isolated from Sarcandra glabra.
- Formula: C15H18O4
- Molecular Weight: 262.30
8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, has anti-LIMK1 activity. 8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide has inhibitory property on cell motility.
- Formula: C16H20O4
- Molecular Weight: 276.33
8-epi-Chlorajapolide F (compound 1) a sesquiterpene that can be isolated from the aboveground part of the Chloranthus japonicus. 8-epi-Chlorajapolide has few cytotoxic to human cancer cell lines NCI-H460 and SMMC-7721 (IC50s>50 μg/mL).
- Formula: C15H18O4
- Molecular Weight: 262.30
Chloranthalactone E (compound 6), a labdane diterpene, can be isolated from the aerial parts of Chloranthus serratus. Chloranthalactone E inhibits NO production in LPS-activated RAW 264.7 macrophages.
