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Cat. No.: HY-N10913

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Chloranthalactone B

Chloranthalactone B, a lindenane-type sesquiterpenoid, is a nature product that could be isolated from Chinese medicinal herb Sarcandra glabra. Chloranthalactone B inhibits the production of inflammatory mediators by inhibiting the AP-1 and p38 MAPK pathways.

For research use only. We do not sell to patients.

CAS No.: 66395-03-7
Formula: C₁₅H₁₆O₃
Molecular Weight:244.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Chloranthalactone B Chemical Structure

CAS No.: 66395-03-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All AP-1 Isoforms :

All p38 MAPK Isoforms :

All NO Synthase Isoforms :

All TNF Receptor Isoforms :

All COX Isoforms :

All Interleukin Related Isoforms :

In Vitro

Chloranthalactone B (6.25-50 µM; 30 min) has anti-inflammatory effects in LPS-stimulated RAW264.7 cells and inhibits NO production^[1].
Chloranthalactone B (25 and 50 µM; 30 min) inhibits inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor α (TNF-α), and interleukin-1β (IL-1β) expression in LPS-treated RAW264.7 cells^[1].
Chloranthalactone B (25 and 50 µM; RAW264.7 cells) inhibits LPS-induced AP-1 activation in a concentration-dependent manner^[1].
Chloranthalactone B (25 and 50 µM; 30 min; RAW264.7 cells) inhibits the phosphorylation of ERK, JNK, and p38 in RAW264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

RAW264.7 cells
Concentration:

25 and 50 µM
Incubation Time:

30 min
Result:

Inhibited the expression of iNOS, TNF-α, COX-2, and IL-1β in a dose-dependent manner.
Inhibited the phosphorylation of ERK, JNK, and p38 in RAW264.7 cells.

Chemical Information

CAS No. 66395-03-7
Molecular Weight 244.29
Formula C₁₅H₁₆O₃
SMILES

C[C@@]12[C@@]3([H])[C@]4(O3)C(C[C@@]1([H])C([C@]5([H])[C@@]2([H])C5)=C)=C(C(O4)=O)C
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li X, et, al. Anti-Inflammatory Effects of Chloranthalactone B in LPS-Stimulated RAW264.7 Cells. Int J Mol Sci. 2016 Nov 22;17(11):1938. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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Chloranthalactone B

All AP-1 Isoforms

All p38 MAPK Isoforms

All NO Synthase Isoforms

All TNF Receptor Isoforms

All COX Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Chloranthalactone B Related Classifications

HY-N10913 Related Classifications