1. Immunology/Inflammation MAPK/ERK Pathway Apoptosis
  2. AP-1 p38 MAPK NO Synthase TNF Receptor COX Interleukin Related
  3. Chloranthalactone B

Chloranthalactone B, a lindenane-type sesquiterpenoid, is a nature product that could be isolated from Chinese medicinal herb Sarcandra glabra. Chloranthalactone B inhibits the production of inflammatory mediators by inhibiting the AP-1 and p38 MAPK pathways.

For research use only. We do not sell to patients.

Chloranthalactone B Chemical Structure

Chloranthalactone B Chemical Structure

CAS No. : 66395-03-7

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Description

Chloranthalactone B, a lindenane-type sesquiterpenoid, is a nature product that could be isolated from Chinese medicinal herb Sarcandra glabra. Chloranthalactone B inhibits the production of inflammatory mediators by inhibiting the AP-1 and p38 MAPK pathways[1].

In Vitro

Chloranthalactone B (6.25-50 µM; 30 min) has anti-inflammatory effects in LPS-stimulated RAW264.7 cells and inhibits NO production[1].
Chloranthalactone B (25 and 50 µM; 30 min) inhibits inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor α (TNF-α), and interleukin-1β (IL-1β) expression in LPS-treated RAW264.7 cells[1].
Chloranthalactone B (25 and 50 µM; RAW264.7 cells) inhibits LPS-induced AP-1 activation in a concentration-dependent manner[1].
Chloranthalactone B (25 and 50 µM; 30 min; RAW264.7 cells) inhibits the phosphorylation of ERK, JNK, and p38 in RAW264.7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 25 and 50 µM
Incubation Time: 30 min
Result: Inhibited the expression of iNOS, TNF-α, COX-2, and IL-1β in a dose-dependent manner.
Inhibited the phosphorylation of ERK, JNK, and p38 in RAW264.7 cells.
Molecular Weight

244.29

Formula

C15H16O3

CAS No.
SMILES

C[C@@]12[C@@]3([H])[C@]4(O3)C(C[C@@]1([H])C([C@]5([H])[C@@]2([H])C5)=C)=C(C(O4)=O)C

Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Chloranthalactone B
Cat. No.:
HY-N10913
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