Chloranthaceae
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- Sarcandra glabrai> (Thunb.) Nakai (10)
- Chloranthus erectusi> (Buchanan-Hamilton) Verdcourt (8)
- Chloranthus serratusi> (Thunb.) Roem. et Schult. (8)
- Chloranthus spicatusi> (Thunb.) Makino (8)
- Chloranthus japonicusi> Sieb. (5)
- Chloranthus fortuneii> (A. Gray) Solms-Laub (2)
- Chloranthus henryii> Hemsl. (2)
- Chloranthus holostegiusi> (Hand.-Mazz.) Pei et Shan (2)
- Chloranthus anhuiensisi> K. F. Wu (1)
- Chloranthus serratusi> var. taiwanensis K. F. Wu (1)
- Hedyosmum brasiliensei> Mart. (1)
- Sarcandra glabrai> subsp. brachystachysi> (Blume) Verdcourt (1)
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Chloranthaceae (52)
- Formule: C40H44O13
- Masse moléculaire: 732.77
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression.
- Formule: C31H34O6
- Masse moléculaire: 502.60
Shizukaol A is an sesquiterpene dimer that can be isolated from Chloranthus japonicas.
- Formule: C17H18O4
- Masse moléculaire: 286.32
Chlojaponilactone B is a lindenane-type sesquiterpenoid with anti-inflammatory properties. Chlojaponilactone B suppresses inflammatory responses by inhibiting TLR4 and subsequently decreasing reactive oxygen species (ROS) generation, downregulating the NF-κB, thus reducing the expression of the pro-inflammatory cytokines iNOS, NO, COX-2, IL-6 and TNF-α.
- Formule: C15H16O3
- Masse moléculaire: 244.29
- Formule: C39H42O14
- Masse moléculaire: 734.74
Chloramultilide B is a lindenane dimer that can be isolated from Chloranthus serratus. Chloramultilide B has inhibitory activities against Candida albicans and C.parapsilosis with a MIC value of 0.068 μM.
- Formule: C17H16O4
- Masse moléculaire: 284.31
(E/Z)-Flavokawain B (compound 4) is a chalcone and nitric oxide production inhibitor with an IC50 of 6.8 μM.(E/Z)-Flavokawain B can be found in the aerial parts of Sarcandra glabra.(E/Z)-Flavokawain B inhibits lipopolysaccharide-induced nitric oxide production.
- Formule: C33H36O9
- Masse moléculaire: 576.63
Chlorahololide C, a lindenane sesquiterpenoid dimer, is isolated from Chloranthus holostegius. Chlorahololide C is a potent and selective potassium channel blocker, with an IC50 of 3.6 μM.
- Formule: C15H20O3
- Masse moléculaire: 248.32
Shizukolidol is an antimicrobial agent that can be isolated from polyfollicles of Magnolia vovidessi. Shizukolidol shows antibacterial activity against Chryseobacterium sp. Shizukolidol can be used for the research of bacterial infection.
- Formule: C27H32O5
- Masse moléculaire: 436.54
Glabralide A is a natural chalcone.
- Formule: C21H26O3
- Masse moléculaire: 326.43
Glabralide B is a natural phenolic compound.
- Formule: C17H20O4
- Masse moléculaire: 288.34
Chloranthalactone C (Compound 43), a lindenane-type sesquiterpenoid, is an antimalarial agent. Chloranthalactone C can be isolated from plant Chloranthus japonicas Sieb. Chloranthalactone C inhibits Chloroquine (HY-17589A)-resistant Plasmodium falciparum strain Dd2 growth. Chloranthalactone C can be used for parasitic infections research.
- Formule: C15H18O3
- Masse moléculaire: 246.30
Chlorantholide C, an eudesmane-type sesquiterpene lactone, can be isolated from Chloranthus elatior.
- Formule: C33H38O9
- Masse moléculaire: 578.65
- Formule: C38H44O12
- Masse moléculaire: 692.75
Sarglaroids F (compound 6) is an anti-inflammatory agent isolated from the roots of Grass Coral. Sarglaroids F inhibits LPS/ATP-induced IL-1β release by affecting K+ efflux and reducing Caspase-1(P20) levels. Sarglaroids F is not cytotoxic to RAW264.7 cells.
- Formule: C15H26O2
- Masse moléculaire: 238.37
Aromadendrane-4β,10α-diol is a sesquiterpene alcohol. Aromadendrane-4β,10α-diol significantly ameliorates the Aβ1-42 peptide-induced memory impairment. Aromadendrane-4β,10α-diol can be used for Alzheimer's disease (AD) research.
- Formule: C32H36O8
- Masse moléculaire: 548.62
Cycloshizukaol A is a symmetrical cyclic lindenane dimer with C2 symmetry. Cycloshizukaol A can be isolated from the root of Chloranthus serratus.
- Formule: C29H40O4
- Masse moléculaire: 452.63
Glabralide C is a meroterpenoid. Glabralide C can be isolated from Sarcandra glabra.
- Formule: C15H18O4
- Masse moléculaire: 262.30
8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, has anti-LIMK1 activity. 8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide has inhibitory property on cell motility.
- Formule: C16H20O4
- Masse moléculaire: 276.33
8-epi-Chlorajapolide F (compound 1) a sesquiterpene that can be isolated from the aboveground part of the Chloranthus japonicus. 8-epi-Chlorajapolide has few cytotoxic to human cancer cell lines NCI-H460 and SMMC-7721 (IC50s>50 μg/mL).
