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Diclofenac diethylamine

24 Cited Publications
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Based on 24 publication(s) in Google Scholar

Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

For research use only. We do not sell to patients.

  • Purity: 99.95%
  • CAS No.: 78213-16-8
  • Formula: C18H22Cl2N2O2
  • Molecular Weight:369.29
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Diclofenac diethylamine Chemical Structure
    Diclofenac diethylamine Chemical Structure
  • Experimental Validation Results for Diclofenac diethylamine
  • Experimental Validation Results for Diclofenac diethylamine
  • Experimental Validation Results for Diclofenac diethylamine
  • Experimental Validation Results for Diclofenac diethylamine
  • Experimental Validation Results for Diclofenac diethylamine
  • Experimental Validation Results for Diclofenac diethylamine
  • Experimental Validation Results for Diclofenac diethylamine
  • Experimental Validation Results for Diclofenac diethylamine
  • Experimental Validation Results for Diclofenac diethylamine
  • Experimental Validation Results for Diclofenac diethylamine
  • Experimental Validation Results for Diclofenac diethylamine
  • Experimental Validation Results for Diclofenac diethylamine
CAS No.: 78213-16-8
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  • Diclofenac diethylamine Chemical Structure
    Diclofenac diethylamine Chemical Structure
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  • 1/16

    Diclofenac diethylamine purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2026 Feb 3.

    Customer Validation
     Cumulative release of DS (Diclofenac Sodium; 50 μg/mL; 0-24 h) from HDPCK hydrogels. DS showed rapid initial release, with approximately 80% released within half a day, followed by gradual release associated with hydrogel degradation.

  • 1/16

    Diclofenac diethylamine purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2026 Feb 3.

    Customer Validation
     Intracellular ROS was visualized in chondrocytes stimulated with IL-1β and then co-cultured for 1 day with HDPC or HDPCK hydrogels containing DS (Diclofenac Sodium; 50 μg/mL); “+” groups received 808 nm NIR irradiation (0.75 W/cm²; 7 min). DS-containing hydrogels reduced intracellular ROS compared with the inflamed control group.

  • 1/16

    Diclofenac diethylamine purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2026 Feb 3.

    Customer Validation
     Chondrocyte apoptosis was analyzed by flow cytometry after IL-1β-stimulated chondrocytes were co-cultured for 1 day with HDPC or HDPCK hydrogels containing DS (Diclofenac Sodium; 50 μg/mL). DS-containing hydrogels reduced both early and late apoptosis, with the strongest effects observed in the NIR-assisted groups.

  • 1/16

    Diclofenac diethylamine purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2026 Feb 3.

    Customer Validation
     Immunofluorescence staining and semi-quantification of Col II, ACAN, and MMP13 were performed in IL-1β-stimulated chondrocytes after exposure to HDPC or HDPCK hydrogels containing DS (Diclofenac Sodium; 50 μg/mL; 1 day). DS-containing hydrogels restored Col II and ACAN expression while MMP13 was suppressed, with the most pronounced changes in the HDPCK+ group.

  • 1/16

    Diclofenac diethylamine purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2026 Feb 3.

    Customer Validation
     RT-qPCR analysis of Col II, Acan, and Mmp13 mRNA expression was performed in IL-1β-stimulated chondrocytes after exposure to HDPC or HDPCK hydrogels containing DS (Diclofenac Sodium; 50 μg/mL; 1 day). Hydrogel exposure upregulated Col II and Acan and downregulated Mmp13, with the most significant changes in the HDPCK+ group.

  • 1/16

    Diclofenac diethylamine purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2026 Feb 3.

    Customer Validation
     Western blotting was used to analyze proteins involved in inflammation-, cell metabolism-, and growth-related pathways in chondrocytes under IL-1β-induced inflammatory conditions following exposure to HDPCK or HDPCK+ hydrogels containing DS (Diclofenac Sodium; 50 μg/mL; 1 day).

  • 1/16

    Diclofenac diethylamine purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2026 Feb 3.

    Customer Validation
     H&E and Safranin O/Fast Green (SO/FG) staining of articular cartilage was performed in ACLT-induced osteoarthritis rats after intra-articular administration of HDPC or HDPCK hydrogels containing DS (Diclofenac Sodium; 50 μg/mL; i.a.; once every 2 weeks for 6 weeks). The results of H&E staining and SO/FG staining showed that the PBS group exhibited severe cartilage degeneration with significant loss of proteoglycans, whereas the treatment groups displayed effective cartilage protection.

  • 1/16

    Diclofenac diethylamine purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2026 Feb 3.

    Customer Validation
     Immunohistochemical staining and semi-quantification of Col II and ACAN were performed in ACLT-induced osteoarthritis rats after intra-articular administration of HDPC or HDPCK hydrogels containing DS (Diclofenac Sodium; 50 μg/mL; i.a.; once every 2 weeks for 6 weeks). After the incorporation of photothermal therapy and DS, articular cartilage was effectively protected.

  • 1/16

    Diclofenac diethylamine purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Oct 11;23(20):12066. [Abstract]

    Customer Validation
     KATOIII and KATO/DDP were treated with different concentration of Diclofenac (DCF) (0–1000 µM) for 48 h, and cell viability was assessed.

  • 1/16

    Diclofenac diethylamine purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Oct 11;23(20):12066. [Abstract]

    Customer Validation
     The KATO/DDP cells were treated with Cisplatin alone or cisplatin in combination with Diclofenac (DCF) at 10 or 20 µM for 24 h, at 37 °C. The apoptosis cells were detected by using annexin V and PI staining and analyzed by flow cytometer.

  • 1/16

    Diclofenac diethylamine purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Oct 11;23(20):12066. [Abstract]

    Customer Validation
     The combination effect of Diclofenac (DCF) (0, 5, 10, 20 μM) and Cisplatin on the expression of cleaved PARP in KATO/DDP cells was examined by Western blot analysis.

  • 1/16

    Diclofenac diethylamine purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Oct 11;23(20):12066. [Abstract]

    Customer Validation
     The formation of autophagic vacuoles in KATO/DDP cells increased from 27% to 39% and 45% in cotreatments involving cisplatin and Diclofenac (DCF) at 10 and 20 μM, respectively, when compared with treatment of cisplatin alone.

  • Diclofenac diethylamine