2. Immunology/Inflammation
  3. Interleukin Related
  4. Vobarilizumab

Vobarilizumab  (Synonyms: ALX-0061)

Cat. No.: HY-P99385 Purity: 97.36%
COA

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Vobarilizumab (ALX-0061) is an anti-IL-6R monoclonal antibody (mAb) (Kd: 0.19 pM). Vobarilizumab consists of an anti-IL-6R domain and an anti-human serum albumin domain. Vobarilizumab can be used in the research of inflammatory autoimmune diseases, such as rheumatoid arthritis.

For research use only. We do not sell to patients.

Vobarilizumab Chemical Structure

Vobarilizumab Chemical Structure

CAS No. : 1628814-88-9

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Vobarilizumab Related Antibodies

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Description

Vobarilizumab (ALX-0061) is an anti-IL-6R monoclonal antibody (mAb) (Kd: 0.19 pM). Vobarilizumab consists of an anti-IL-6R domain and an anti-human serum albumin domain. Vobarilizumab can be used in the research of inflammatory autoimmune diseases, such as rheumatoid arthritis[1][2][3].

In Vitro

Vobarilizumab shows a preferential binding affinity for sIL-6R compared with mIL-6R[2].
Vobarilizumab (0-10 nM) blocks the interaction of recombinant hIL-6 to recombinant hsIL-6R[3].
Vobarilizumab (0-100 nM) blocks proliferation of the TF-1 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Vobarilizumab Related Antibodies
In Vivo

Vobarilizumab (0.4-10 mg/kg, i.v.) inhibits hIL-6-induced inflammation in cynomolgus monkey[3].
Vobarilizumab (0.4-10 mg/kg, i.v.) shows a prolonged exposure through binding to serum albumin in cynomolgus monkeys[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: hIL-6-induced inflammation in cynomolgus monkey[3]
Dosage: 0.4 mg/kg, 2 mg/kg, or 10 mg/kg
Administration: Intravenous injection (i.v.)
Result: Inhibited the acute phase response parameters: plasma levels of C-reactive protein (CRP), fibrinogen and platelets.
Animal Model: Cynomolgus monkeys[3]
Dosage: 0.4 mg/kg, 2 mg/kg, or 10 mg/kg
Administration: Intravenous injection (i.v.)
Result: Pharmacokinetic parameters of Vobarilizumab
dose (mg/kg) T1/2 dominant (day) AUCinf (μg/day/mL) CL (mL/day/kg) Vss (mL/kg)
0.4 (i.v.) 1.73 16.3 24.8 42.8
2 (i.v.) 5.0 193 10.4 53.7
10 (i.v.) 6.61 1136 9 82.7
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Vobarilizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 97.36%

COA (231 KB)

Handling Instructions (2659 KB)
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Vobarilizumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vobarilizumab1628814-88-9ALX-0061ALX0061ALX 0061Interleukin RelatedILRheumatoid arthritisRATF-1 cellhIL-6inflammationInhibitorinhibitorinhibit

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