2. Anti-infection Apoptosis
  3. Bacterial Apoptosis
  4. Epimedokoreanin B

Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation.

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Epimedokoreanin B Chemical Structure

Epimedokoreanin B Chemical Structure

CAS No. : 161068-53-7

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Epimedokoreanin B Related Antibodies

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Description

Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation[1][2][3].

In Vitro

Epimedokoreanin B (compound6; 3.13-25 μM; 48 hours) shows significate inhibitory effect on proliferation against lung cancer cell A549, Calu1 and H1299. Epimedokoreanin B displays no toxic on human bronchial epithelial cells BEAS-2B[1]. Epimedokoreanin B treatment inhibits cell proliferation and migration accompanied by cytoplasmic vacuolation in A549 and NCI-H292 cells. Atophagosome accumulation accompanied with autophagy flux blocking is observed in Epimedokoreanin B treated cells, this was consistent with the occurrence of ER stress[2].
Epimedokoreanin B (5 μM; 24 hours) inhibits CD163 expression and IL-10 production, which are known M2 markers, suggesting that Epimedokoreanin B inhibits M2 polarization in human monocyte-derived macrophages (HMDMs). Epimedokoreanin B suppresses STAT3 activation in HMDMs[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Epimedokoreanin B Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: A549, Calu1 and H1299 cells
Concentration: 3.13 μM, 6.25 μM, 12.5 μM and 25.0 μM
Incubation Time: 48 hours
Result: Showed significate inhibitory effect on proliferation against lung cancer cell A549, Calu1 and H1299.

Western Blot Analysis[4]

Cell Line: Human monocyte-derived macrophages (HMDMs)
Concentration: 5 μM
Incubation Time: 24 hours
Result: Significantly suppressed IL-10-induced JAK1/STAT3 activation.and H1299.
In Vivo

Epimedokoreanin B (20 mg/kg; p.o; thrice a week; for 17 days) inhibits tumor growth in an LM8 tumor-bearing murine model[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C3H mice (8-10 weeks old) injected with LM8 cells[4]
Dosage: 20 mg/kg
Administration: Oral administration; thrice a week; for 17 days
Result: Inhibited tumor growth.
Molecular Weight

422.47

Formula

C25H26O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C=C(C2=CC(C/C=C(C)\C)=C(O)C(O)=C2)OC3=C(C/C=C(C)\C)C(O)=CC(O)=C13
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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Epimedokoreanin B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Epimedokoreanin B161068-53-7BacterialApoptosisflavonoidanticanceranti-inflammatory and antibacterial effectsanti-periodontitis agentSTAT3lung cancer cellsInhibitorinhibitorinhibit

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