161068-53-7
Chemical Structure
Epimedokoreanin B
- CAS No.: 161068-53-7
- Formula:C25H26O6
- Molecular Weight:422.47
IUPAC Name: 2-(3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl)-5,7-dihydroxy-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
InChIKey: QLZMBCVLWOJASJ-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC(C/C=C(C)\C)=C(O)C(O)=C2)OC3=C(C/C=C(C)\C)C(O)=CC(O)=C13
Biological Activity: Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation[1][2][3].
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Epimedokoreanin B | 98.86% | Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation. | ||||||||||||||||||||
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References
- [1]. Huaran Zhang, et al. Flavonoids from the leaves of Epimedium Koreanum Nakai and their potential cytotoxic activities. Nat Prod Res. 2020 May;34(9):1256-1263. [Content Brief]
- [2]. Hao Zheng, et al. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated paraptosis accompanied by autophagosome accumulation. Chem Biol Interact. 2022 Oct 1;366:110125. [Content Brief]
- [3]. T Kariu, et al. Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenyl flavonoids. J Periodontal Res. 2017 Feb;52(1):89-96. [Content Brief]
