2. GPCR/G Protein
  3. GCGR
  4. Glepaglutide acetate

Glepaglutide acetate  (Synonyms: ZP1848 acetate)

Cat. No.: HY-P2221B Purity: 98.47%
COA Handling Instructions

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Glepaglutide (ZP1848) acetate, a long-acting GLP-2 analogue, is a potent GLP-2R agonist. Glepaglutide acetate reduces faecal output and increases intestinal absorption. Glepaglutide acetate alleviates small intestinal inflammation. Glepaglutide acetate can be used in the research of inflammatory bowel disease (IBD) and Crohn’s disease.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Glepaglutide acetate Chemical Structure

Glepaglutide acetate Chemical Structure

Size Price Stock Quantity
1 mg USD 130 In-stock
5 mg USD 320 In-stock
10 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Glepaglutide acetate:

Glepaglutide acetate Related Antibodies

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  • Purity & Documentation

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Description

Glepaglutide (ZP1848) acetate, a long-acting GLP-2 analogue, is a potent GLP-2R agonist. Glepaglutide acetate reduces faecal output and increases intestinal absorption. Glepaglutide acetate alleviates small intestinal inflammation. Glepaglutide acetate can be used in the research of inflammatory bowel disease (IBD) and Crohn’s disease[1][2][3].

IC50 & Target

GLP-2R[3]
In Vivo

Glepaglutide (ZP1848; 200 and 400 nmol/kg, s.c., twice a day for 14 days) acetate shows intestinotrophic effect in rats with small intestinal inflammation[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats with Indomethacin (HY-14397)-induced small intestinal inflammation[3]
Dosage: 200 and 400 nmol/kg
Administration: Subcutaneousinjection (s.c.), twice a day for 14 days
Result: Increased plasma citrulline concentration.
Increased small intestinal mass.
Decreased small intestinal concentrations of the inflammatory marker (AGP and MPO).
Clinical Trial
Molecular Weight

4376.06

Formula

C199H329N53O57
Appearance

Solid

Color

White to off-white

Sequence

His-Gly-Glu-Gly-Thr-Phe-Ser-Ser-Glu-Leu-Ala-Thr-Ile-Leu-Asp-Ala-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Ala-Trp-Leu-Ile-Ala-Thr-Lys-Ile-Thr-Asp-Lys-Lys-Lys-Lys-Lys-Lys-NH2
Sequence Shortening

HGEGTFSSELATILDALAARDFIAWLIATKITDKKKKKK-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (11.43 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2285 mL 1.1426 mL 2.2852 mL
5 mM 0.0457 mL 0.2285 mL 0.4570 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.47%

COA (246 KB) RP-HPLC (562 KB) MS (82 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.2285 mL 1.1426 mL 2.2852 mL 5.7129 mL
5 mM 0.0457 mL 0.2285 mL 0.4570 mL 1.1426 mL
10 mM 0.0229 mL 0.1143 mL 0.2285 mL 0.5713 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Glepaglutide acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GlepaglutideZP1848ZP 1848ZP-1848GCGRGlucagon ReceptorShort bowel syndromeGLP-2long-actingIBDintestinal inflammationInhibitorinhibitorinhibit

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