Sulfosuccinimidyl oleate
Based on 45 publication(s) in Google Scholar
Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect.
For research use only. We do not sell to patients.
- CAS No.: 135661-44-8
- Formula: C22H37NO7S
- Molecular Weight:459.60
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Sulfosuccinimidyl oleate
More- Adv Mater. 2026 Jun;38(33):e21108. [Abstract]
- Cancer Res. 2025 Apr 28:OF1-OF13. [Abstract]
- Nat Commun. 2026 May 11;17(1):4190. [Abstract]
- ACS Nano. 2026 Jun 2;20(21):15384-15409. [Abstract]
- Redox Biol. 2025 Mar:80:103528. [Abstract]
- Adv Sci (Weinh). 2026 Jun 2:e75875. [Abstract]
- Cell Rep Med. 2024 Jun 18;5(6):101592. [Abstract]
- Cell Death Dis. 2025 Apr 14;16(1):291. [Abstract]
- Cell Death Dis. 2024 Aug 26;15(8):623. [Abstract]
- Cancer Lett. 2024 Jan 28:581:216511. [Abstract]
- J Exp Med. 2023 Mar 6;220(3):e20221316. [Abstract]
- J Transl Med. 2023 Feb 6;21(1):89. [Abstract]
- Food Res Int. 2026 Mar 31:228:118352. [Abstract]
- Food Res Int. 2023 Nov;173(Pt 1):113328. [Abstract]
- Int J Biol Macromol. 2023 Dec 31;253(Pt 8):127324. [Abstract]
- Cell Rep. 2026 Feb 24;45(2):116952. [Abstract]
- Cell Rep. 2024 Oct 19;43(11):114881. [Abstract]
- Cell Rep. 2024 Jul 9;43(7):114465. [Abstract]
- J Invest Dermatol. 2025 Nov 20:S0022-202X(25)03555-9. [Abstract]
- Cancer Cell Int. 2025 May 14;25(1):176. [Abstract]
- JCI Insight. 2025 Feb 18;10(6):e184935. [Abstract]
- J Agric Food Chem. 2026 Feb 11;74(5):4407-4419. [Abstract]
- J Agric Food Chem. 2024 Jul 24;72(29):16287-16297. [Abstract]
- CNS Neurosci Ther. 2023 Jun;29 Suppl 1(Suppl 1):161-184. [Abstract]
- Cancer Metab. 2025 Feb 7;13(1):6. [Abstract]
- Nutrients. 2025 Feb 25;17(5):794. [Abstract]
- Int Immunopharmacol. 2026 Apr 27:181:116718. [Abstract]
- Int Immunopharmacol. 2026 Mar 1:172:116231. [Abstract]
- Int Immunopharmacol. 2025 Dec 10:167:115594. [Abstract]
- Int J Mol Sci. 2025 Apr 8;26(8):3482. [Abstract]
- Int J Mol Sci. 2023 Aug 31;24(17):13516. [Abstract]
- Front Pharmacol. 2020 Dec 16:11:593832. [Abstract]
- Toxicol Sci. 2023 Feb 17;191(2):276-284. [Abstract]
- Food Sci Nutr. 2023 Nov 22;12(2):1318-1329. [Abstract]
- BMC Cancer. 2023 Apr 21;23(1):367. [Abstract]
- Toxins. 2021 Nov 13;13(11):802. [Abstract]
- Cell Immunol. 2022 Feb:372:104475. [Abstract]
- Fish Physiol Biochem. 2025 Nov 24;51(6):197. [Abstract]
- bioRxiv. 2026 May 29.
- SSRN. 2025 Oct 22.
- University of Chicago. 2025 Aug.
- Heliyon. 2024 Nov 28;10(23):e40806. [Abstract]
- Research Square Preprint. 2023 Oct 11.
- SSRN. 2023 Aug 30.
- Research Square Print. December 29th, 2022.
-
IF
-
Cell Imaging/Staining
-
In Vivo Imaging
-
WB
-
In Vivo Efficacy Study
Biological Activity
Sulfosuccinimidyl oleate (20 μM and 50 μM, 24 hours) alone does not alter the cellular viability. Exposure to 100 ng/ml LPS+5 ng/mL IFNγ modestly, yet significantly reduces the viability of the BV2 cells. Co-treatment with Sulfosuccinimidyl oleate prevents the LPS+IFNγ-induced reduction in the cell viability[1].
Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:BV2 cells
-
Concentration:20 μM and 50 μM
-
Incubation Time:24 hours
-
Result:Did not alter the viability of BV2 cells alone. Exposure of BV2 cells to 100 ng/mL LPS and 5 ng/mL IFNγ significantly reduced the viability of BV2 cells while simultaneous treatment with Sulfosuccinimidyl oleate prevented it.
-
Cell Line:BV2 cells
-
Concentration:50 μM
-
Incubation Time:24 hours
-
Result:Drastically increased the levels of NOS2, COX-2, and P-p38/T-p38.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:4-month-old male BALB/cABom mice with pMCAo model[1]
-
Dosage:50 mg/kg
-
Administration:Administered once by single oral gavage
-
Result:Reduced brain damage following ischemia. Attenuated infarct size.
Chemical Information
-
CAS No. 135661-44-8
-
Molecular Weight 459.60
-
Formula C22H37NO7S
-
SMILES
O=S(C(C1)C(N(OC(CCCCCCC/C=C\CCCCCCCC)=O)C1=O)=O)(O)=O
-
Synonyms
Sulfo-N-succinimidyl oleate
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (45)
-
Journal Impact Factor
-
Most Recent
-
Adv Mater
Conformationally Variable Peptides Trap and Detoxify Ox-LDL in Plaques for Attenuating Atherosclerosis in Multiple Species. [Abstract]2026 Jun;38(33):e21108. PMID: 42116761 -
Cancer Res
Blocking the TCA Cycle in Cancer Cells Potentiates CD36+ T-cell-Mediated Antitumor Immunity by Suppressing ER Stress-Associated THBS2 Signaling. [Abstract]2025 Apr 28:OF1-OF13. PMID: 40293258 -
Nat Commun
Ascites protects against ferroptosis and enables the peritoneal growth of ovarian cancer. [Abstract]2026 May 11;17(1):4190. PMID: 42115216 -
ACS Nano
Injectable Binary-Amplified Cascade Hydrogels Suppress Post-Incomplete Microwave Ablation Relapse via Integrated Metallo-Metabolic-Immunomodulation. [Abstract]2026 Jun 2;20(21):15384-15409. PMID: 42150126 -
Redox Biol
Niraparib restricts intraperitoneal metastases of ovarian cancer by eliciting CD36-dependent ferroptosis. [Abstract]2025 Mar:80:103528. PMID: 39922130
Sulfosuccinimidyl oleate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Mar:80:103528. [Abstract]
OVCAR8 cells were cultured in fatty acid-free media supplemented with 1.0 μL/mL exogenous fatty acids and treated with 10 μМ Niraparib, 100 μМ SSO (sulfosuccinimidyl oleate), or a combination for 72 h. Representative C1 BODIPY 500/510C12 staining images were shown. Scale bar=50 μm. The intensity of C1 BODIPY 500/510C12 staining was assessed by Image Pro Plus 6.0.
Sulfosuccinimidyl oleate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Mar:80:103528. [Abstract]
OVCAR8 cells were cultured in fatty acid-free media supplemented with 1.0 μL/mL exogenous fatty acids and treated with 10 μМ Niraparib, 100 μМ SSO (sulfosuccinimidyl oleate), or a combination for 72 h. The ROS levels were measured by flow cytometry.
Sulfosuccinimidyl oleate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Mar:80:103528. [Abstract]
Tp53-deficient ID8 tumor-bearing mice were administered with Niraparib (50 mg/kg) from day 6, and administered with Lipro-1 (10 mg/kg, intraperitoneally, a single dose) and SSO (sulfosuccinimidyl oleate) (50 mg/kg, intragastrically, a single dose) from day 3. Representative actual or bioluminescent images of mice after a 3-week treatment.
-
Adv Sci (Weinh)
CEBPG-Mediated Palmitic Acid Adaptation of Cancer-Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma. [Abstract]2026 Jun 2:e75875. PMID: 42227941 -
Cell Rep Med
A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML. [Abstract]2024 Jun 18;5(6):101592. PMID: 38843841
Sulfosuccinimidyl oleate purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2024 Jun 18;5(6):101592. [Abstract]
AML cells labeled with a chemical probe (alk-C16) for 4 h in the presence of Sulfosuccinimidyl oleate (SSO) (50 μM) were used for palmitoylation assay.
-
Cell Death Dis
A targetable antioxidant defense mechanism to EZH2 inhibitors enhances tumor cell vulnerability to ferroptosis. [Abstract]2025 Apr 14;16(1):291. PMID: 40229247 -
Cell Death Dis
TREM2-dependent activation of microglial cell protects photoreceptor cell during retinal degeneration via PPARγ and CD36. [Abstract]2024 Aug 26;15(8):623. PMID: 39187498
Sulfosuccinimidyl oleate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2024 Aug 26;15(8):623. [Abstract]
Quantitative analysis of the outer nuclear layer thickness in SSO (sulfosuccinimidyl oleate) (50 mg/kg, oral gavage)-treated MNU-induced WT mouse retina and GW1929 (30 mg/kg, intraperitoneal injection, twice)+SSO treated MNU-induced Trem2−/− mouse retina.
-
Cancer Lett
PA suppresses antitumor immunity of T cells by disturbing mitochondrial activity through Akt/mTOR-mediated Ca2+ flux. [Abstract]2024 Jan 28:581:216511. PMID: 38013049 -
J Exp Med
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition. [Abstract]2023 Mar 6;220(3):e20221316. PMID: 36520461 -
J Transl Med
Young and undamaged recombinant albumin alleviates T2DM by improving hepatic glycolysis through EGFR and protecting islet β cells in mice. [Abstract]2023 Feb 6;21(1):89. PMID: 36747238 -
Food Res Int
Hydroxypropyl-β-cyclodextrin as a co-delivery vehicle for synergistically enhancing fucoxanthin oral bioavailability through dual regulation of SR-B1 and ABCB1 transporters. [Abstract]2026 Mar 31:228:118352. PMID: 41703824 -
Food Res Int
Cluster-determinant 36 (CD36) mediates intestinal absorption of dietary astaxanthin and affects its secretion. [Abstract]2023 Nov;173(Pt 1):113328. PMID: 37803639 -
Int J Biol Macromol
Stearic acid promotes lipid synthesis through CD36/Fyn/FAK/mTORC1 axis in bovine mammary epithelial cells. [Abstract]2023 Dec 31;253(Pt 8):127324. PMID: 37838116 -
Cell Rep
Tfam-mediated metabolic perturbation in RORγt+ lymphocytes impacts intestinal tissue homeostasis and promotes GATA3+RORγt+ innate lymphoid cells. [Abstract]2026 Feb 24;45(2):116952. PMID: 41678335 -
Cell Rep
CD36-mediated arachidonic acid influx from decidual stromal cells increases inflammatory macrophages in miscarriage. [Abstract]2024 Oct 19;43(11):114881. PMID: 39427314 -
Cell Rep
Excessive free fatty acid sensing in pituitary lactotrophs elicits steatotic liver disease by decreasing prolactin levels. [Abstract]2024 Jul 9;43(7):114465. PMID: 38985678 -
J Invest Dermatol
CD36-mediated long-chain fatty acids transport in keratinocytes promotes psoriasis-like skin inflammation by increasing mitochondrial ROS. [Abstract]2025 Nov 20:S0022-202X(25)03555-9. PMID: 41274545 -
Cancer Cell Int
BCR::ABL1 expression in chronic myeloid leukemia cells in low oxygen is regulated by glutamine via CD36-mediated fatty acid uptake. [Abstract]2025 May 14;25(1):176. PMID: 40369538 -
JCI Insight
Complement activation at the interface between adipocytes and cancer cells drives tumor progression. [Abstract]2025 Feb 18;10(6):e184935. PMID: 39964754 -
J Agric Food Chem
Intestinal Absorption of Dietary Astaxanthin Mediated by Cluster-Determinant 36 (CD36) Presents Stereoisomeric Selectivity In Vitro and In Vivo. [Abstract]2026 Feb 11;74(5):4407-4419. PMID: 41631482 -
J Agric Food Chem
Cluster of Differentiation 36 (CD36) Preferentially Mediates Intestinal Absorption of Dietary Z-Astaxanthin and Especially 9- Z-Isomer via Higher Binding Affinity. [Abstract]2024 Jul 24;72(29):16287-16297. PMID: 38986018 -
CNS Neurosci Ther
Tongqiao Huoxue Decoction ameliorates traumatic brain injury-induced gastrointestinal dysfunction by regulating CD36/15-LO/NR4A1 signaling, which fails when CD36 and CX3CR1 are deficient. [Abstract]2023 Jun;29 Suppl 1(Suppl 1):161-184. PMID: 37157929 -
Cancer Metab
CD36 inhibition enhances the anti-proliferative effects of PI3K inhibitors in PTEN-loss anti-HER2 resistant breast cancer cells. [Abstract]2025 Feb 7;13(1):6. PMID: 39920872 -
Nutrients
Medium-Chain Fatty Acids Selectively Sensitize Cancer Cells to Ferroptosis by Inducing CD36 and ACSL4. [Abstract]2025 Feb 25;17(5):794. PMID: 40077664 -
Int Immunopharmacol
Aloe-emodin promotes remyelination by driving microglial myelin debris clearance via the CD36-PPARγ axis. [Abstract]2026 Apr 27:181:116718. PMID: 42048733 -
Int Immunopharmacol
Rutin ameliorates hepatic ischemia-reperfusion injury by targeting CD36 to suppress hepatocyte ferroptosis. [Abstract]2026 Mar 1:172:116231. PMID: 41576568 -
Int Immunopharmacol
CD36-mediated fatty acid metabolic reprogramming activates synovial fibroblasts and promotes rheumatoid arthritis progression. [Abstract]2025 Dec 10:167:115594. PMID: 41101221 -
Int J Mol Sci
CD36 Induces Inflammation by Promoting Ferroptosis in Pancreas, Epididymal Adipose Tissue, and Adipose Tissue Macrophages in Obesity-Related Severe Acute Pancreatitis. [Abstract]2025 Apr 8;26(8):3482. PMID: 40331957 -
Int J Mol Sci
Chlorogenic Acid Alleviates LPS-Induced Inflammation and Oxidative Stress by Modulating CD36/AMPK/PGC-1α in RAW264.7 Macrophages. [Abstract]2023 Aug 31;24(17):13516. PMID: 37686324 -
Front Pharmacol
Carnosine Stimulates Macrophage-Mediated Clearance of Senescent Skin Cells Through Activation of the AKT2 Signaling Pathway by CD36 and RAGE. [Abstract]2020 Dec 16:11:593832. PMID: 33390976 -
Toxicol Sci
2,3,7,8-Tetrachlorodibenzo-dioxin induces liver lipid metabolism disorder via the ROS/AMPK/CD36 signaling pathway. [Abstract]2023 Feb 17;191(2):276-284. PMID: 36534932 -
Food Sci Nutr
The effect of in vitro digestion on the interaction between polysaccharides derived from Pleurotus eryngii and intestinal mucus. [Abstract]2023 Nov 22;12(2):1318-1329. PMID: 38370047 -
BMC Cancer
Tumor-infiltrating CD36+CD8+T cells determine exhausted tumor microenvironment and correlate with inferior response to chemotherapy in non-small cell lung cancer. [Abstract]2023 Apr 21;23(1):367. PMID: 37085798 -
Toxins
2021 Nov 13;13(11):802. PMID: 34822586 -
Cell Immunol
2022 Feb:372:104475. PMID: 35063904 -
Fish Physiol Biochem
Central administration of docosahexaenoic acid, eicosapentaenoic acid, or linoleic acid activates hypothalamic fatty acid sensing and is involved in reproductive regulation in spotted scat (Scatophagus argus). [Abstract]2025 Nov 24;51(6):197. PMID: 41284092 -
-
-
-
Heliyon
CB2R activation enhances tumor-associated macrophages-mediated phagocytosis of glioma cell. [Abstract]2024 Nov 28;10(23):e40806. PMID: 39691192 -
-
-
Purity & Documentation
References
[1]. Dhungana H, et al. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. J Neuroinflammation. 2017 Dec 4;14(1):237. [Content Brief]
[2]. Drahota Z, et al. Succinimidyl oleate, established inhibitor of CD36/FAT translocase inhibits complex III of mitochondrial respiratory chain. Biochem Biophys Res Commun. 2010 Jan 15;391(3):1348-51. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)