1. Others
  2. Others
  3. Sulfosuccinimidyl oleate

Sulfosuccinimidyl oleate 

Cat. No.: HY-112847
Handling Instructions

Sulfosuccinimidyl oleate is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect.

For research use only. We do not sell to patients.

Sulfosuccinimidyl oleate Chemical Structure

Sulfosuccinimidyl oleate Chemical Structure

CAS No. : 135661-44-8

Size Price Stock
5 mg USD 190 Get quote
10 mg USD 320 Get quote

* Please select Quantity before adding items.

Other In-stock Forms of Sulfosuccinimidyl oleate:

Other Forms of Sulfosuccinimidyl oleate:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Sulfosuccinimidyl oleate is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect[1].

In Vitro

Sulfosuccinimidyl oleate (20 μM and 50 μM, 24 hours) alone does not alter the cellular viability. Exposure to 100 ng/ml LPS+5 ng/mL IFNγ modestly, yet significantly reduces the viability of the BV2 cells. Co-treatment with Sulfosuccinimidyl oleate prevents the LPS+IFNγ-induced reduction in the cell viability[1].
Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours)[1].

Cell Viability Assay[1]

Cell Line: BV2 cells
Concentration: 20 μM and 50 μM
Incubation Time: 24 hours
Result: Did not alter the viability of BV2 cells alone. Exposure of BV2 cells to 100 ng/mL LPS and 5 ng/mL IFNγ significantly reduced the viability of BV2 cells while simultaneous treatment with Sulfosuccinimidyl oleate prevented it.

Western Blot Analysis[1]

Cell Line: BV2 cells
Concentration: 50 μM
Incubation Time: 24 hours
Result: Drastically increased the levels of NOS2, COX-2, and P-p38/T-p38.
In Vivo

Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls in male BALB/cABom mice with pMCAo model. In addition, Sulfosuccinimidyl oleate at 50 mg/kg is suitable to see a beneficial effect after stroke[1].

Animal Model: 4-month-old male BALB/cABom mice with pMCAo model[1]
Dosage: 50 mg/kg
Administration: Administered once by single oral gavage
Result: Reduced brain damage following ischemia. Attenuated infarct size.
Molecular Weight

459.60

Formula

C₂₂H₃₇NO₇S

CAS No.

135661-44-8

SMILES

O=S(C(C1)C(N(OC(CCCCCCC/C=C\CCCCCCCC)=O)C1=O)=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Sulfosuccinimidyl oleate
Cat. No.:
HY-112847
Quantity: