2. Immunology/Inflammation Stem Cell/Wnt Apoptosis Autophagy
  3. COX Wnt Apoptosis Autophagy
  4. Ginkgetin

Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC50 of 5.92 μΜ.

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CAS No. : 481-46-9

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10 mM * 1 mL in DMSO
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Based on 13 publication(s) in Google Scholar

Other Forms of Ginkgetin:

Ginkgetin Related Antibodies

Top Publications Citing Use of Products

    Ginkgetin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov 19:e2407222.  [Abstract]

    Ginkgetin (2 µM; 48 h) downregulated the expression of CDKis, including p16 and p21, as well as SASP-related genes such as Il6 and Il1b in MEFs.

    Ginkgetin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov 19:e2407222.  [Abstract]

    Ginkgetin (2 µM; 48 h) decreased the number of SA-β-gal positive cells among MEFs.

    Ginkgetin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov 19:e2407222.  [Abstract]

    (5 mg/kg; i.p.; once every 2 days for 2 months) reduced the aggregation of immune cells in the kidney and liver of C57BL/6J mice injected with Dox.

    Ginkgetin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov 19:e2407222.  [Abstract]

    Ginkgetin (5 mg/kg; i.p.; once every 2 days for 2 months) diminished the accumulation of SA‐β‐Gal positive senescent cells in the kidney of C57BL/6J mice injected with Dox.

    Ginkgetin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov 19:e2407222.  [Abstract]

    Ginkgetin (5 mg/kg; i.p.; once every 2 days for 2 months) efficiently alleviated physical dysfunction of C57BL/6J mice injected with Dox.

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    • Biological Activity

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    Description

    Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC50 of 5.92 μΜ[1][2][3][4][5].

    Cellular Effect
    Cell Line Type Value Description References
    OVCAR-3 IC50
    1.8 μg/mL
    Compound: 1
    Growth inhibition of human OVCAR-3 cells after 48 hrs
    Growth inhibition of human OVCAR-3 cells after 48 hrs
    		[PMID: 9134745]
    In Vitro

    Ginkgetin (2.5-20 μM; 48 h) inhibits the growth of Daoy and D283 cell lines, and induces G2/M cell cycle arrest in Daoy cells[2].
    Ginkgetin (20-40 μM; 24 h) significantly activates the apoptosis of osteosarcoma cells in a concentration-dependent manner[3].
    Ginkgetin (10-20 μM; 3-24 h) down-regulated the expression of Wnt target genes without affecting the expression of β-catenin in medulloblastoma cells[2].
    Ginkgetin (1-10 μM; 24 or 48 h) significantly inhibits the VEGF-induced endothelial cell proliferation, migration, and wound recovery in a concentration-dependent manner[1].
    Ginkgetin (5-10 μM; 48 h) induces autophagy responsible for cell death in A549[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ginkgetin Related Antibodies

    Cell Viability Assay[2]

    Cell Line: Daoy and D283 cell lines
    Concentration: 2.5, 5, 10, 20 μM
    Incubation Time: 48 hours
    Result: Inhibited the cell growth, with IC50s of 14.65 and 15.81 μM for Daoy and D283 cells, respectively.

    Apoptosis Analysis[3]

    Cell Line: Osteosarcoma cells
    Concentration: 20, 30, 40 μM
    Incubation Time: 24 hours
    Result: Markedly induced the apoptosis of osteosarcoma cells in a concentration-dependent manner.

    Cell Cycle Analysis[2]

    Cell Line: Daoy cells
    Concentration: 2.5, 5, 10, 20 μM
    Incubation Time: 24 hours
    Result: Increased G2/M phase, compared with that of control, indicating a G2/M cell phase arrest.

    Cell Cycle Analysis[2]

    Cell Line: Daoy and D283 cell lines
    Concentration: 10, 20 μM
    Incubation Time: 3, 6, 12, 24 hours
    Result: Attenuated the expression of Wnt target genes, Axin2, cyclin D1 and survivin at 20 μM for 24 h in Daoy cells.
    Unaffected the level of total β-catenin and diminished the level of β-catenin phosphorylation in a time- and concentration-dependent manner.
    In Vivo

    Ginkgetin (25-100 mg/kg; i.p. 2 hours after the onset of ischemia) exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway[4].
    Ginkgetin (30 mg/kg; intragastrically once per day for 42 d) suppresses tumor growth in A549 cells bearing nude mice[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Sprague-Dawley rats (200-220 g)[4]
    Dosage: 25, 50, 100 mg/kg
    Administration: I.p. 2 hours after the onset of ischemia
    Result: Reduced the neurological deficit score.
    Suppressed the expression of NF-κB, TLR4 and IκBαin ischemic penumbra cortex, and inhibited the degradation of IκBα.
    Decreased the expressions of ICAM-1, COX-2, and iNOS.
    Downregulated downstream inflammatory factor PGE2 and TNF-α expression.
    Decreased IL-1β, IL-6, IL-8, and IL-10 protein expression.
    Molecular Weight

    566.51

    Formula

    C32H22O10
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    OC1=CC(O)=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=C1C4=CC(C(OC5=CC(OC)=CC(O)=C56)=CC6=O)=CC=C4OC
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 20.83 mg/mL (36.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7652 mL 8.8260 mL 17.6519 mL
    5 mM 0.3530 mL 1.7652 mL 3.5304 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  50% PEG300    50% Saline

      Solubility: 2 mg/mL (3.53 mM); Suspended solution; Need ultrasonic and warming

    • Protocol 2

      Add each solvent one by one:  0.5% CMC-Na/saline water

      Solubility: 2 mg/mL (3.53 mM); Suspended solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.87%

    SDS (393 KB)

    COA (250 KB) HNMR (305 KB) RP-HPLC (245 KB) MS (70 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.7652 mL 8.8260 mL 17.6519 mL 44.1298 mL
    5 mM 0.3530 mL 1.7652 mL 3.5304 mL 8.8260 mL
    10 mM 0.1765 mL 0.8826 mL 1.7652 mL 4.4130 mL
    15 mM 0.1177 mL 0.5884 mL 1.1768 mL 2.9420 mL
    20 mM 0.0883 mL 0.4413 mL 0.8826 mL 2.2065 mL
    25 mM 0.0706 mL 0.3530 mL 0.7061 mL 1.7652 mL
    30 mM 0.0588 mL 0.2942 mL 0.5884 mL 1.4710 mL
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    Ginkgetin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ginkgetin481-46-9COXWntApoptosisAutophagyCyclooxygenasebiflavoneGinkgobilobaleavesanti-tumoranti-inflammatoryneuroprotectiveanti-fungalsignalingInhibitorinhibitorinhibit

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