Selective cytotoxicity of ginkgetin from Selaginella moellendorffii

  • J Nat Prod. 1997 Apr;60(4):382-4. doi: 10.1021/np960608e.
C M Sun  1 ,  W J Syu ,  Y T Huang ,  C C Chen ,  J C Ou
Affiliations
  • 1. National Research Institute of Chinese Medicine, Taipei, Taiwan.
PMID: 9134745 DOI: 10.1021/np960608e
Abstract

Bioassay-directed fractionation of an ethanolic extract of Selaginella moellendorffii has led to the isolation of a known biflavone, ginkgetin (1). A dose-dependent inhibition was observed with 1 on the growth of OVCAR-3 (human ovarian adenocarcinoma) cells with 50% inhibition occurring at 1.8 micrograms/mL. Nonbioactive fractions yielded four additional known Biflavones, amentoflavone 7,4',7",4"'-tetramethyl ether, kayaflavone, podocarpusflavone A, and amentoflavone.

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