481-46-9
481-46-9
Chemical Structure
Ginkgetin
- No. CAS: 481-46-9
- Formula:C32H22O10
- Molecular Weight:566.51
IUPAC Name: 5,7-dihydroxy-8-(5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-2-(4-hydroxyphenyl)-4H-chromen-4-one
InChIKey: AIFCFBUSLAEIBR-UHFFFAOYSA-N
SMILES: OC1=CC(O)=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=C1C4=CC(C(OC5=CC(OC)=CC(O)=C56)=CC6=O)=CC=C4OC
Biological Activity: Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC50 of 5.92 μΜ[1][2][3][4][5].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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Ginkgetin | 99.87% | Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC50 of 5.92 μΜ. | ||||||||||||||||||||
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Ginkgetin (Standard) | ≥98% | Ginkgetin (Standard) is the analytical standard of Ginkgetin. This product is intended for research and analytical applications. Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC50 of 5.92 μΜ. | ||||||||||||||||||||
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Sequoiaflavone | Sequoiaflavone is a biflavonoid compound with multiple activities. Sequoiaflavone suppresses hepatic CYP1A1/(7-Ethoxycoumarin O-deethylase) ECOD, prevents Aβ1-42 fibrillization (IC50 = 0.29 μM) and disaggregates amyloid fibrils (EC50 = 2.04 μM), inhibits Alternaria alternata and inhibits human recombinant PDE5A1 overexpressed in COS-7 cells (IC50 = 19.9 μM) to exert NO-independent vasodilation. Sequoiaflavone can be used in Alzheimer's disease, peripheral circulatory disorder, and antifungal research. | |||||||||||||||||||||
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Taiwanhomoflavone A | Taiwanhomoflavone A is a C-methylated biflavone, that can be isolated from the stem of Cephalotaxus wilsoniana. Taiwanhomoflavone-A shows anticancer activity. | |||||||||||||||||||||
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Podocarpusflavone B | Podocarpusflavone B is a bisflavone that can be isolated from Padocarpus macraphylla. | |||||||||||||||||||||
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Amentoflavone 7'',4'''-dimethyl ether | Amentoflavone 7'',4'''-dimethyl ether is a natural flavonoid. | |||||||||||||||||||||
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Isoginkgetin | 99.91% | Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy. | ||||||||||||||||||||
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Bilobetin (Standard) | ≥98% | Bilobetin (Standard) is the analytical standard of Bilobetin. This product is intended for research and analytical applications. Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity. | ||||||||||||||||||||
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Sciadopitysin (Standard) | ≥98% | Sciadopitysin (Standard) is the analytical standard of Sciadopitysin. This product is intended for research and analytical applications. Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1. | ||||||||||||||||||||
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Amentoflavone 7,4',7'',4'''-tetramethyl ether | 97.0% | Amentoflavone 7,4',7'',4'''-tetramethyl ether, a biflavone, is a natural product that can be isolated from Selaginella moellendorffii. | ||||||||||||||||||||
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Heveaflavone | Heveaflavone is an anticancer and antioxidant agent. | |||||||||||||||||||||
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Kayaflavone | 96.0% | Kayaflavone is a biflavonoid compound from the seed kernel of Torreya grandis. Kayaflavone exhibits anticancer activity and is cytotoxic to human tumor cell lines. Kayaflavone inhibits amyloid-β toxicity in PC-12 cells with an EC50 of 5.29 μM. Kayaflavone is predicted to bind to the catalytic site of the SARS-CoV-2 main protease (Mpro/3CLpro) and block enzyme activity, indicating potential antiviral activity. Kayaflavone can be used in cancer-related research, such as cervical cancer and breast cancer, as well as in research related to neurological diseases. | ||||||||||||||||||||
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References
- [1]. Hu WH, et, al. Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer. Cancers (Basel). 2019 Nov 20;11(12):1828. [Content Brief]
- [2]. Ye ZN, et, al. Biflavone Ginkgetin, a Novel Wnt Inhibitor, Suppresses the Growth of Medulloblastoma. Nat Prod Bioprospect. 2015 Mar 29;5(2):91-97. [Content Brief]
- [3]. Xiong M, et, al. Ginkgetin exerts growth inhibitory and apoptotic effects on osteosarcoma cells through inhibition of STAT3 and activation of caspase-3/9. Oncol Rep. 2016 Feb;35(2):1034-40. [Content Brief]
- [4]. Li Q, et, al. Ginkgetin exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway. Biosci Biotechnol Biochem. 2019 Apr;83(4):675-683. [Content Brief]
- [5]. Lou J, et, al. Ginkgetin induces autophagic cell death through p62/SQSTM1-mediated autolysosome formation and redox setting in non-small cell lung cancer. Oncotarget. 2017 Oct 16;8(54):93131-93148. [Content Brief]
