1. Metabolic Enzyme/Protease
    PI3K/Akt/mTOR
    NF-κB
    Apoptosis
    Autophagy
  2. MMP
    Akt
    NF-κB
    Proteasome
    Apoptosis
    Autophagy
  3. Isoginkgetin

Isoginkgetin 

Cat. No.: HY-N2117 Purity: 99.73%
Handling Instructions

Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy.

For research use only. We do not sell to patients.

Isoginkgetin Chemical Structure

Isoginkgetin Chemical Structure

CAS No. : 548-19-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 165 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 105 In-stock
Estimated Time of Arrival: December 31
10 mg USD 176 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 7 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy[1][2].

In Vitro

Isoginkgetin (0-20 μM, 24 h) inhibits cell invasion in a dose-dependent manner[1].
Isoginkgetin (10 μM, 0-24 h) induces the accumulation of ubiquitinated protein cargo into perinuclear aggregates, activates autophagy and induces lysosomal swelling, repositioning, and acidification[2].
Isoginkgetin (10 μM, 0-6 h) induces ER stress, impairs the unfolded protein response, and results in accumulation of ERAD substrates[2].
Isoginkgetin directly inhibits the chymotrypsin-, trypsin-, and caspase-like activities of the 20S proteasome and impairs NF-κB signaling[2].
Isoginkgetin (30 μM, 0-24 h) induces apoptosis in MM cell lines[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Invasion Assay[1]

Cell Line: MDA-MB-231 and B16F10
Concentration: 0, 5, 10 and 20 μM
Incubation Time: 24 h
Result: Inhibited cell invasion in a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: HeLa cells and MM cell lines (MM1S, 8826, OPM2, H929, JJN3 and U266)
Concentration: 10 μM in HeLa cells, 30 μM in MM cell lines
Incubation Time: 0-24 h
Result: Induced the expression of cleaved PARP-1 and Casp-3. Increased the protein levels of both ATF4 and ATF3. Decreased the level of LC3 I. Increased TFEB activation. Prevented the degradation of IκBα in response to stimulation with TNF-α.

Cell Viability Assay[2]

Cell Line: MM1S, 8826, OPM2, H929, JJN3 and U266 cells
Concentration:
Incubation Time: 72 h
Result: Inhibited cell viability with IC50 values of 3.992, 3.716, 4.749, 2.564, 3.806 and 4.147 μM against MM1S, 8826, OPM2, H929, JJN3 and U266 cells, respectively.
In Vivo

Isoginkgetin (4 mg/kg; i.p.; daily for 14 days) shows anti-inflammatory effects[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Kunming mice (age 8–10weeks, 30–50 g)[3]
Dosage: 4 mg/kg
Administration: Daily for 14 days by intraperitoneally (i.p.) prior to LPS (0.83mg/kg) administration.
Result: Markedly suppressed the production of IL-1β, IL-6, tumor necrosis factor-alpha, cyclooxygenase-2, inducible nitric oxide, and reactive oxygen species.
Molecular Weight

566.51

Formula

C32H22O10

CAS No.
SMILES

O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(O)C=C6O5)=O)=CC=C4OC)C(O)=CC(O)=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (176.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7652 mL 8.8260 mL 17.6519 mL
5 mM 0.3530 mL 1.7652 mL 3.5304 mL
10 mM 0.1765 mL 0.8826 mL 1.7652 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.67 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (3.67 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.73%

References
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Product Name:
Isoginkgetin
Cat. No.:
HY-N2117
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