548-19-6
548-19-6
Chemical Structure
Isoginkgetin
- CAS No.: 548-19-6
- Formula:C32H22O10
- Molecular Weight:566.51
IUPAC Name: 8-(5-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
InChIKey: HUOOMAOYXQFIDQ-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(O)C=C6O5)=O)=CC=C4OC)C(O)=CC(O)=C13
Biological Activity: Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Isoginkgetin | 99.91% | Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy. | ||||||||||||||||||||
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Isoginkgetin (Standard) | ≥98% | Isoginkgetin (Standard) is the analytical standard of Isoginkgetin. This product is intended for research and analytical applications. Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy. | ||||||||||||||||||||
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Ginkgetin | 99.87% | Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC50 of 5.92 μΜ. | ||||||||||||||||||||
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Podocarpusflavone B | Podocarpusflavone B is a bisflavone that can be isolated from Padocarpus macraphylla. | |||||||||||||||||||||
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Amentoflavone 7'',4'''-dimethyl ether | Amentoflavone 7'',4'''-dimethyl ether is a natural flavonoid. | |||||||||||||||||||||
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Bilobetin | 99.71% | Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity. | ||||||||||||||||||||
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Sciadopitysin | 99.0% | Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1. | ||||||||||||||||||||
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Podocarpusflavone A | 99.62% | Podocarpusflavone A is a biflavonoid present in the leaves of Podocarpus henkelii, with anti-tumor, topoisomerase I inhibitory, antibacterial and antifungal activities. Podocarpusflavone A exhibits antibacterial activity against Enterococcus faecalis and Pseudomonas aeruginosa. Podocarpusflavone A shows weak activity against fungal pathogens. Podocarpusflavone A targets topoisomerase I and induces cell cycle arrest and apoptosis in MCF-7 cells. Podocarpusflavone A can be used for studies on cancer, bacterial and fungal infections. | ||||||||||||||||||||
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Sotetsuflavone | Sotetsuflavone is a flavonoid that can be isolated from Cycas revolute. Sotetsuflavone inhibits phosphorylation of PI3K, Akt, mTOR, JNK, and p38 MAPK; modulates expression of Cyclin D1, CDK4, Bcl-2, Bax, cleaved caspases 3/9, MMP-9, TGF-β, STAT3, and β-catenin. Sotetsuflavone induces G0/G1 cell cycle arrest, apoptosis, autophagy, and intracellular ROS elevation, inhibits cancer cell proliferation. Sotetsuflavone inhibits tumor growth in mouse tumor xenograft models. Sotetsuflavone can be used for the research of non-small cell lung cancer and Crohn’s disease. | |||||||||||||||||||||
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Amentoflavone 7,4',7'',4'''-tetramethyl ether | 97.0% | Amentoflavone 7,4',7'',4'''-tetramethyl ether, a biflavone, is a natural product that can be isolated from Selaginella moellendorffii. | ||||||||||||||||||||
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Heveaflavone | Heveaflavone is an anticancer and antioxidant agent. | |||||||||||||||||||||
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Kayaflavone | 96.0% | Kayaflavone is a biflavonoid compound from the seed kernel of Torreya grandis. Kayaflavone exhibits anticancer activity and is cytotoxic to human tumor cell lines. Kayaflavone inhibits amyloid-β toxicity in PC-12 cells with an EC50 of 5.29 μM. Kayaflavone is predicted to bind to the catalytic site of the SARS-CoV-2 main protease (Mpro/3CLpro) and block enzyme activity, indicating potential antiviral activity. Kayaflavone can be used in cancer-related research, such as cervical cancer and breast cancer, as well as in research related to neurological diseases. | ||||||||||||||||||||
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References
- [1]. Yoon SO, et al. Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. Mol Cancer Ther. 2006 Nov;5(11):2666-75. [Content Brief]
- [2]. Tsalikis J, et al. Isoginkgetin, a Natural Biflavonoid Proteasome Inhibitor, Sensitizes Cancer Cells to Apoptosis via Disruption of Lysosomal Homeostasis and Impaired Protein Clearance. Mol Cell Biol. 2019 Apr 30;39(10):e00489-18. [Content Brief]
