548-19-6
548-19-6
Chemical Structure
Isoginkgetin
- CAS. Nr.: 548-19-6
- Formula:C32H22O10
- Molecular Weight:566.51
IUPAC Name: 8-(5-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
InChIKey: HUOOMAOYXQFIDQ-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(O)C=C6O5)=O)=CC=C4OC)C(O)=CC(O)=C13
Biological Activity: Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy[1][2].
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Isoginkgetin | 99.91% | Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy. | ||||||||||||||||||||
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Isoginkgetin (Standard) | ≥98% | Isoginkgetin (Standard) is the analytical standard of Isoginkgetin. This product is intended for research and analytical applications. Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.93
HY-N2118Bilobetin -
Similarity Score 0.93
HY-N0889Ginkgetin -
Similarity Score 0.92
HY-N2119Sciadopitysin -
Similarity Score 0.92
HY-N16767Amentoflavone 7'',4'''-dimethyl ether -
Similarity Score 0.91
HY-N9861Kayaflavone -
Similarity Score 0.91
HY-N2198Podocarpusflavone A -
Similarity Score 0.89
HY-N1575Podocarpusflavone B -
Similarity Score 0.86
HY-N4047Heveaflavone -
Similarity Score 0.85
HY-N2199Sotetsuflavone -
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References
- [1]. Yoon SO, et al. Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. Mol Cancer Ther. 2006 Nov;5(11):2666-75. [Content Brief]
- [2]. Tsalikis J, et al. Isoginkgetin, a Natural Biflavonoid Proteasome Inhibitor, Sensitizes Cancer Cells to Apoptosis via Disruption of Lysosomal Homeostasis and Impaired Protein Clearance. Mol Cell Biol. 2019 Apr 30;39(10):e00489-18. [Content Brief]
