1. Cell Cycle/DNA Damage
  2. Topoisomerase

Podocarpusflavone A 

Cat. No.: HY-N2198
Handling Instructions

Podocarpusflavone A is a DNA topoisomerase I inhibitor, have moderated anti-proliferative activity induce cell apoptosis in MCF-7, is developing anti-tumor drugs target: DNA topoisomerase I In vitro: podocarpusflavone-A show significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED50 4.56-16.24 μg/mL) and induce cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest.

For research use only. We do not sell to patients.
Podocarpusflavone A Chemical Structure

Podocarpusflavone A Chemical Structure

CAS No. : 22136-74-9

Size Price Stock
5 mg USD 216 Get quote
10 mg USD 336 Get quote

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Description

Podocarpusflavone A is a DNA topoisomerase I inhibitor, have moderated anti-proliferative activity induce cell apoptosis in MCF-7, is developing anti-tumor drugs target: DNA topoisomerase I In vitro: podocarpusflavone-A show significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED50 4.56-16.24 μg/mL) and induce cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest. PF (40 ug/mL, 24 hr) significantly induced about 10 folds of cell deaths and growth arrest in S-phase than the control group.

IC50 & Target[1]

Topoisomerase I

119.425 μM (IC50)

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.8100 mL 9.0501 mL 18.1002 mL
5 mM 0.3620 mL 1.8100 mL 3.6200 mL
10 mM 0.1810 mL 0.9050 mL 1.8100 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

552.48

Formula

C₃₁H₂₀O₁₀

CAS No.

22136-74-9

SMILES

O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(O)C=C6O5)=O)=CC=C4O)C(O)=CC(O)=C13

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Podocarpusflavone A
Cat. No.:
HY-N2198
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