1. Cell Cycle/DNA Damage
    Apoptosis
  2. Topoisomerase
    Apoptosis
  3. Podocarpusflavone A

Podocarpusflavone A 

Cat. No.: HY-N2198
Handling Instructions

Podocarpusflavone A is a DNA topoisomerase I inhibitor, have moderated anti-proliferative activity induce cell apoptosis in MCF-7, is developing anti-tumor drugs target: DNA topoisomerase I In vitro: podocarpusflavone-A show significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED50 4.56-16.24 μg/mL) and induce cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest.

For research use only. We do not sell to patients.

Podocarpusflavone A Chemical Structure

Podocarpusflavone A Chemical Structure

CAS No. : 22136-74-9

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Description

Podocarpusflavone A is a DNA topoisomerase I inhibitor, have moderated anti-proliferative activity induce cell apoptosis in MCF-7, is developing anti-tumor drugs target: DNA topoisomerase I In vitro: podocarpusflavone-A show significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED50 4.56-16.24 μg/mL) and induce cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest. PF (40 ug/mL, 24 hr) significantly induced about 10 folds of cell deaths and growth arrest in S-phase than the control group.

IC50 & Target[1]

Topoisomerase I

119.425 μM (IC50)

Molecular Weight

552.48

Formula

C₃₁H₂₀O₁₀

CAS No.

22136-74-9

SMILES

O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(O)C=C6O5)=O)=CC=C4O)C(O)=CC(O)=C13

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Keywords:

Podocarpusflavone ATopoisomeraseApoptosisInhibitorinhibitorinhibit

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Podocarpusflavone A
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