Natural inhibitors targeting osteoclast-mediated bone resorption

  • Bioorg Med Chem Lett. 2006 Dec 15;16(24):6178-80. doi: 10.1016/j.bmcl.2006.09.042.
Guang-Zhi Zeng  1 ,  Ning-Hua Tan ,  Xiao-Jiang Hao ,  Quan-Zhang Mu ,  Rong-Tao Li
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China; Graduate School of the Chinese Academy of Sciences, Beijing 100039, China.
PMID: 17027271 DOI: 10.1016/j.bmcl.2006.09.042
Abstract

Human Cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3) Integrin are the key regulators in osteoclast-mediated bone resorption. In this paper, we found natural inhibitors 1-10 for them by enzyme inhibition assays. Inhibitors 1-7, 8-9, and 10 are novel inhibitors of human Cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3), respectively.