1. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
    Apoptosis
    Anti-infection
  2. Reactive Oxygen Species
    Apoptosis
    Bacterial
    Fungal
    RSV
  3. Amentoflavone

Amentoflavone (Synonyms: Didemethyl-ginkgetin)

Cat. No.: HY-N0662 Purity: 99.80%
Handling Instructions

Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects.

For research use only. We do not sell to patients.

Amentoflavone Chemical Structure

Amentoflavone Chemical Structure

CAS No. : 1617-53-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 83 In-stock
Estimated Time of Arrival: December 31
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 110 In-stock
Estimated Time of Arrival: December 31
25 mg USD 190 In-stock
Estimated Time of Arrival: December 31
50 mg USD 320 In-stock
Estimated Time of Arrival: December 31
100 mg USD 520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

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Publications Citing Use of MCE Amentoflavone

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Description

Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects. IC50 value: Target: In vitro: In irradiated v79 cells, Pretreatment with amentoflavone 24 hours prior to 8 Gy 60Co γ-ray irradiation significantly inhibited apoptosis, promoted the G2 phase, decreased the concentration of ROS and mitochondrial mass [2]. Amentoflavone dose-dependently inhibited the viability of SW480 cells, and a high concentration of amentoflavone (150 μmol/L) obviously induced apoptosis of the cells [3]. In vivo: In epilepsy models, amentoflavone effectively prevented pilocarpine-induced epilepsy in a mouse kindling model, suppressed nuclear factor-κB activation and expression, inhibited excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and apoptosis of hippocampal neurons [1].

Molecular Weight

538.46

Formula

C₃₀H₁₈O₁₀

CAS No.

1617-53-4

SMILES

O=C1C=C(C2=CC=C(O)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(O)C=C6O5)=O)=CC=C4O)C(O)=CC(O)=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (185.71 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8571 mL 9.2857 mL 18.5715 mL
5 mM 0.3714 mL 1.8571 mL 3.7143 mL
10 mM 0.1857 mL 0.9286 mL 1.8571 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.64 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (4.64 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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Keywords:

AmentoflavoneDidemethyl-ginkgetinReactive Oxygen SpeciesApoptosisBacterialFungalRSVRespiratory syncytial virusInhibitorinhibitorinhibit

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Amentoflavone
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