Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla

  • J Nat Prod. 2000 Jun;63(6):753-6. doi: 10.1021/np990478k.
J S Lee  1 ,  J Kim ,  B Y Kim ,  H S Lee ,  J S Ahn ,  Y S Chang
Affiliations
  • 1. College of Pharmacy, Seoul National University, Seoul 151-742, Korea, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea.
PMID: 10869194 DOI: 10.1021/np990478k
Abstract

Investigation of the hooks of Uncaria rhynchophylla resulted in isolation of six Phospholipase Cgamma1 (PLCgamma1) inhibitors (1-6). The structures of these compounds were elucidated as pentacyclic triterpene esters by spectroscopic and chemical analysis. Three of them, namely uncarinic acids C (1), D (2), and E (3), are newly reported as natural products. All the compounds showed dose-dependent inhibitory activities against PLCgamma1 in vitro with IC(50) values of 9.5-44.6 microM and inhibited the proliferation of human Cancer cells with IC(50) values of 0.5-6.5 microg/mL.