1. Metabolic Enzyme/Protease
  2. Phospholipase
  3. CAY10502

CAY10502 

Cat. No.: HY-116301
Handling Instructions

CAY10502 is a potent, calcium-dependent cytosolic phospholipase A2 α (cPLA2α) inhibitor with an IC50 of 4.3 nM for isolated enzyme. CAY10502 can be used in the research of retinopathy and inflammatory diseases.

For research use only. We do not sell to patients.

CAY10502 Chemical Structure

CAY10502 Chemical Structure

CAS No. : 888320-29-4

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Description

CAY10502 is a potent, calcium-dependent cytosolic phospholipase A2 α (cPLA2α) inhibitor with an IC50 of 4.3 nM for isolated enzyme. CAY10502 can be used in the research of retinopathy and inflammatory diseases[1][2][3].

IC50 & Target[1]

cPLA2α

4.3 nM (IC50)

In Vitro

CAY10502 inhibits the release of arachidonic acid mediated by cPLA2R stimulanted with A23187 and TPA in human platelets, with IC50s of 0.57 and 0.0009 μM, respectively[1].
CAY10502 (5, 20, 50 nM; 12 hours; müller cells) inhibits normoxic- and hypoxia-induced Prostaglandin E2 (PGE2) and VEGF production[2].
CAY10502 (0.1-100 nM; 24 hours) inhibits the VEGF-induced proliferation of rat retinal microvascular endothelial cells (RRMEC)[2].
CAY10502 (10 μM) inhibits arachidonic acid (AA) release from the phospholipid pools, abrogated extremely low-frequency electromagnetic fields (ELF-EMF; 1 h) induced AA increase and the ELF-EMF inhibitory effect of Cav3.2 channels[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: RRMEC
Concentration: 0.1-100 nM
Incubation Time: 24 hours
Result: CAY10502 (35, 50 nM) demonstrated significant reductions in VEGF-induced proliferation (64.3% and 84.1%, respectively) compared with cultures treated with VEGF alone.
In Vivo

CAY10502-injected (2.5, 25, 100 nM; 5 μL) eyes demonstrates a dose-dependent inhibition of retinal neovascularization (NV) in rat oxygen-induced retinopathy (OIR)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: OIR and room air (RA) Sprague-Dawley rat[2]
Dosage: 2.5, 25, 100 nM; 5 μL
Administration: Intravitreal Injection
Result: Injection of 100 nM CAY10502 resulted in a 53.1% reduction in NV compared with vehicle treatment.
Molecular Weight

523.62

Formula

C30H37NO7

CAS No.
SMILES

O=C(C1=CN(CC(COC2=CC=C(OCCCCCCCCCC)C=C2)=O)C3=C1C=C(C(O)=O)C=C3)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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