Cat. No.: HY-B2162A

Chondroitin sulfate sodium (from shark cartilage)

Name: Chondroitin sulfate sodium (from shark cartilage)
Brand: MedChemExpress
SKU: HY-B2162A
Price: 50.00 USD
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Rating: 5 (8 reviews)

(Synonyms: Chondroitin polysulfate sodium (from shark cartilage))

8 Cited Publications

Customer Review

Based on 8 publication(s) in Google Scholar

Chondroitin sulfate sodium (from shark cartilage), one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and MMPs.

For research use only. We do not sell to patients.

Purity: 99.52%
CAS No.: 9082-07-9

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Chondroitin sulfate sodium (from shark cartilage) Chemical Structure

CAS No.: 9082-07-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (8)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

iNOS	Human Endogenous Metabolite

All NO Synthase Isoforms :

All MMP Isoforms :

All Endogenous Metabolite Isoforms :

In Vitro

Chondroitin sulfate sodium (from shark cartilage) is a class of sulfated glycosaminoglycans that are linear polysaccharides consisting of repeating disaccharide units composed of uronic acid and N-acetylhexosamine. Several pathogens including parasites, bacteria, and viruses have been shown to utilize cell surface chondroitin sulfate chains to attach to and infect host cells^[1].
Chondroitin sulfate occurs naturally in the extracellular matrix of connective tissues, e.g., bone, cartilage, skin, ligaments and tendons. Chondroitin sulfate has been shown to elicit a range of beneficial effects: anti-inflammatory effects, an increase in type II collagen and proteoglycans, a reduction in bone resorption and a better anabolic/catabolic balance in chondrocytes^[2].
A large range of chondroitin sulfate concentrations has been used (e.g. 12.5 to 2000 mg/mL, but generally less than200 mg/mL) in in vitro studies. Chondroitin sulfate (200 mg/mL) decreases the chondrocyte susceptibility to single nucleotide polymorphism-induced apoptosis^[3].
Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS, MMPs^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The high content of chondroitin sulfate in the aggrecan plays a major part in allowing cartilage to resist tensile stresses during various loading conditions by providing this tissue with resistance and elasticity. It has been shown that chondroitin sulphate interferes with the progression of structural changes in joint tissues and is used in the management of patients with osteoarthritis^[3].
Chondroitin sulfate is mostly administered orally at doses ranging from 800 to 1200mg/day. Chondroitin sulfate is rapidly absorbed by the gastrointestinal tract. The absorbed chondroitin sulfate reaches the blood compartment as 10% chondroitin sulfate and 90% depolymerized low-molecular-weight derivatives^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 9082-07-9
Appearance Solid
Color White to off-white
SMILES

O=S(O)=O.O=S(O)=O.OC([C@@H]1[C@@H](OC)[C@H](O)[C@@H](O)[C@H](O[C@@H]2[C@@H](NC(C)=O)[C@H](OC)O[C@H](CO[R])[C@@H]2O[R])O1)=O.[R].[R].[Na+].[=].[=].[R2=].[R1=].[n].[or]
Synonyms

Chondroitin polysulfate sodium (from shark cartilage)
Structure Classification
- Saccharides
- Polysaccharides
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (8)

All IFIn Vivo Efficacy StudyRT-PCR

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Immunity

Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING. [Abstract]

2021 May 11;54(5):962-975.e8. PMID: 33857420
Acta Pharm Sin B

Sulfation of chondroitin and bile acids converges to antagonize Wnt/ β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis. [Abstract]

2024 Mar;14(3):1241-1256. PMID: 38487006

Chondroitin sulfate sodium (from shark cartilage) purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Mar;14(3):1241-1256. [Abstract]

Representative appearance and Ki67 immunofluorescence of organoids isolated from the ileum of ApcDgut-Het and ApcDgut-HetPapss2Dgut mice and treatment with indicated doses of Chondroitin sulfate (CS, 500 and 1000 mg/mL). Shown on the right are the quantifications of organoid crypts and relative Ki67 signals.

Chondroitin sulfate sodium (from shark cartilage) purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Mar;14(3):1241-1256. [Abstract]

Representative β-catenin immunofluorescence of organoids isolated from the ileum of Apc^Δgut-HetPapss2^Δgut and AOM-treated Papss2^Δgut mice and treatment without or with Chondroitin sulfate. Shown on the right are the quantifications of relative β-catenin signals.

Chondroitin sulfate sodium (from shark cartilage) purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Mar;14(3):1241-1256. [Abstract]

Chondroitin sulfate (CS; 400 mg/kg; daily; PO; 8 weeks) markedly attenuated Papss2 deficiency-induced gut tumorigenesis, as evidenced by the gross appearance of the intestine and colon tissues.

Chondroitin sulfate sodium (from shark cartilage) purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Mar;14(3):1241-1256. [Abstract]

At the histological level, increased tumor morphology and Ki67 immunostaining observed in Apc^Δgut-HetPapss2^Δgut mice were attenuated upon the Chondroitin sulfate (CS; 400 mg/kg; daily; PO; 8 weeks) treatment.

Chondroitin sulfate sodium (from shark cartilage) purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Mar;14(3):1241-1256. [Abstract]

Chondroitin sulfate (CS; 400 mg/kg; daily; PO; 8 weeks) decreased the mRNA expression of Wnt target genes and inflammatory marker genes. Relative ileal mRNA levels of Wnt target genes and pro-inflammatory genes.
Mater Today Bio

Brinzolamide encapsulated β-cyclodextrin-chondroitin sulfate nanocomplexes anchored chitosan/polycaprolactone nanofibers as an ocular insert for glaucoma treatment. [Abstract]

2025 Aug 11:34:102179. PMID: 40838214
Biomater Res

Albumin Nanocages with Methotrexate and Chondroitin Sulfate as a Dual pH/GSH-Responsive Tumor Targeting Nanomedicine for Synergistic Cancer Therapy. [Abstract]

2025 Sep 3:29:0245. PMID: 40908968
Food Biosci

2025 Nov 29.
J Thromb Haemost

Skeletal muscle myosin and cardiac myosin attenuate heparin's antithrombin-dependent anticoagulant activity. [Abstract]

2021 Feb;19(2):470-477. PMID: 33176060
Antibodies

2026 Aug;15(4):52.
FEBS Lett

Thermodynamic profiles of the interactions of suramin, chondroitin sulfate, and pentosan polysulfate with the inhibitory domain of TIMP-3. [Abstract]

2020 Jan;594(1):94-103. PMID: 31359422

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (Need ultrasonic)

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Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mikami T, et al. Biosynthesis and function of chondroitin sulfate. Biochim Biophys Acta. 2013 Oct;1830(10):4719-33. [Content Brief]

[2]. Monfort J, et al. Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues. Ann Rheum Dis. 2008 Jun;67(6):735-40. [Content Brief]

[3]. Martel-Pelletier J, et al.Discrepancies in composition and biological effects of different formulations of chondroitin sulfate. Molecules. 2015 Mar 6;20(3):4277-89. [Content Brief]

[4]. Campo GM, et al. Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes. J Cell Biochem. 2009 Jan 1;106(1):83-92. [Content Brief]

[5]. Henrotin Y, et al. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinicalrecommendations. Ther Adv Musculoskelet Dis. 2010 Dec;2(6):335-48. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Chondroitin sulfate sodium (from shark cartilage)

8 Cited Publications

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