2. MAPK/ERK Pathway Stem Cell/Wnt Immunology/Inflammation Apoptosis GPCR/G Protein Metabolic Enzyme/Protease
  3. ERK p38 MAPK Interleukin Related TNF Receptor Prostaglandin Receptor MMP Endogenous Metabolite
  4. Chondroitin sulfate (from chicken)

Chondroitin sulfate (from chicken)  (Synonyms: Chondroitin polysulfate (from chicken))

Cat. No.: HY-B2162D Purity: 99.61%
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SDS
Handling Instructions Technical Support

Chondroitin sulfate (from chicken) (Chondroitin polysulfate (from chicken)) is an orally active, sulfated linear polysaccharide extracted from chickens, which belongs to glycosaminoglycans. Chondroitin sulfate (from chicken) reduces the phosphorylation levels of ERK1/2 and p38MAPK, inhibits the expression of inflammatory cytokines and MMP, and downregulates the levels of IL-1β, IL-6, TNF-α and PGE2. Chondroitin sulfate (from chicken) improves motor function, protects cartilage tissue, reverses chondrocyte aggregation, and regulates the structure of intestinal flora. Chondroitin sulfate (from chicken) can be used in research related to osteoarthritis.

For research use only. We do not sell to patients.

Chondroitin sulfate (from chicken)

Chondroitin sulfate (from chicken) Chemical Structure

CAS No. : 9007-28-7

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Based on 1 publication(s) in Google Scholar

Other Forms of Chondroitin sulfate (from chicken):

Chondroitin sulfate (from chicken) Related Antibodies

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ERK ERK1 ERK2 ERK5 ERK8

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p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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DP EP FP IP TXA2/TP TXB2

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

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Human Endogenous Metabolite Microbial Metabolite

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Description

Chondroitin sulfate (from chicken) (Chondroitin polysulfate (from chicken)) is an orally active, sulfated linear polysaccharide extracted from chickens, which belongs to glycosaminoglycans. Chondroitin sulfate (from chicken) reduces the phosphorylation levels of ERK1/2 and p38MAPK, inhibits the expression of inflammatory cytokines and MMP, and downregulates the levels of IL-1β, IL-6, TNF-α and PGE2. Chondroitin sulfate (from chicken) improves motor function, protects cartilage tissue, reverses chondrocyte aggregation, and regulates the structure of intestinal flora. Chondroitin sulfate (from chicken) can be used in research related to osteoarthritis[1].

IC50 & Target[1]

ERK1

 

ERK2

 

IL-1β

 

IL-6

 

IL-17

 

In Vivo

Chondroitin sulfate (from chicken) (100 mg/kg/day; p.o.; once daily for 28 days) exerts superior osteoarthritis protective effects in rats induced by Sodium iodoacetate (HY-D0849)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley (SD) (male, 7-8 weeks old, 220 g, sodium iodoacetate-induced osteoarthritis)[1]
Dosage: 100 mg/kg/day
Administration: p.o.; daily; 28 days
Result: Increased rotating rod time and ramp angle with the highest increase rate among tested cartilage extracts, trending closest to the sham group by week 4.
Resulted in intact cartilage surfaces, regular cell arrangement, and intact tide lines via H&E staining; achieved a significantly lower Mankin’s OA score than the osteoarthritis model group and lower than the cartilage powder (CPw) and type II collagen peptides (CP) groups.
Significantly reduced synovial fluid levels of IL-1β, prostaglandin E2 (PGE2), IL-6, and tumor necrosis factor-α (TNF-α) compared to the osteoarthritis model group, with the lowest levels among tested cartilage extracts; modulated serum inflammatory cytokine levels by reducing pro-inflammatory markers relative to the model group.
Altered the gut microbiota structure of osteoarthritis rats, significantly reduced the relative abundance of Lactobacillus compared to the model group; significantly increased ACE index and decreased Simpson index relative to the model group; showed distinct separation from the model group's microbiota profile via principal component analysis.
Formula

(C14H21NO14S)n
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S(O)=O.O=S(O)=O.OC([C@@H]1[C@@H](OC)[C@H](O)[C@@H](O)[C@H](O[C@@H]2[C@@H](NC(C)=O)[C@H](OC)O[C@H](CO[R])[C@@H]2O[R])O1)=O.[R].[R].[=].[=].[R2=].[R1=].[n].[or]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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Purity & Documentation

Purity: 99.61%

SDS (394 KB)

COA (258 KB) RP-HPLC (252 KB)

Handling Instructions (2659 KB)
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Chondroitin sulfate (from chicken) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chondroitin sulfate (from chicken)9007-28-7Chondroitin polysulfate (from chicken)ERKp38 MAPKInterleukin RelatedTNF ReceptorProstaglandin ReceptorMMPEndogenous MetaboliteExtracellular signal regulated kinasesILTumor Necrosis Factor ReceptorTNFRMatrix metalloproteinaseschondrocytesTLR4CD44interleukin-1 receptor-associated kinase-MICAM1MKP-1p38MAPKNF-κBosteoarthritisERK1/2Inhibitorinhibitorinhibit

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