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Cat. No.: HY-B2162D

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Chondroitin sulfate (from chicken)

Name: Chondroitin sulfate (from chicken)
Brand: MedChemExpress
SKU: HY-B2162D
Price: 52.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Chondroitin polysulfate (from chicken))

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Chondroitin sulfate (from chicken) (Chondroitin polysulfate (from chicken)) is an orally active, sulfated linear polysaccharide extracted from chickens, which belongs to glycosaminoglycans. Chondroitin sulfate (from chicken) reduces the phosphorylation levels of ERK1/2 and p38MAPK, inhibits the expression of inflammatory cytokines and MMP, and downregulates the levels of IL-1β, IL-6, TNF-α and PGE₂. Chondroitin sulfate (from chicken) improves motor function, protects cartilage tissue, reverses chondrocyte aggregation, and regulates the structure of intestinal flora. Chondroitin sulfate (from chicken) can be used in research related to osteoarthritis.

For research use only. We do not sell to patients.

Purity: 99.61%
CAS No.: 9007-28-7
Formula: (C₁₄H₂₁NO₁₄S)n

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Chondroitin sulfate (from chicken) Chemical Structure

CAS No.: 9007-28-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target^[1]

ERK1

ERK2

IL-1β

IL-6

IL-17

All ERK Isoforms :

All p38 MAPK Isoforms :

All Interleukin Related Isoforms :

All TNF Receptor Isoforms :

All Prostaglandin Receptor Isoforms :

All MMP Isoforms :

All Endogenous Metabolite Isoforms :

In Vivo

Chondroitin sulfate (from chicken) (100 mg/kg/day; p.o.; once daily for 28 days) exerts superior osteoarthritis protective effects in rats induced by Sodium iodoacetate (HY-D0849)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley (SD) (male, 7-8 weeks old, 220 g, sodium iodoacetate-induced osteoarthritis)^[1]
Dosage:

100 mg/kg/day
Administration:

p.o.; daily; 28 days
Result:

Increased rotating rod time and ramp angle with the highest increase rate among tested cartilage extracts, trending closest to the sham group by week 4.
Resulted in intact cartilage surfaces, regular cell arrangement, and intact tide lines via H&E staining; achieved a significantly lower Mankin’s OA score than the osteoarthritis model group and lower than the cartilage powder (CPw) and type II collagen peptides (CP) groups.
Significantly reduced synovial fluid levels of IL-1β, prostaglandin E₂ (PGE₂), IL-6, and tumor necrosis factor-α (TNF-α) compared to the osteoarthritis model group, with the lowest levels among tested cartilage extracts; modulated serum inflammatory cytokine levels by reducing pro-inflammatory markers relative to the model group.
Altered the gut microbiota structure of osteoarthritis rats, significantly reduced the relative abundance of Lactobacillus compared to the model group; significantly increased ACE index and decreased Simpson index relative to the model group; showed distinct separation from the model group's microbiota profile via principal component analysis.

Chemical Information

CAS No. 9007-28-7
Appearance Solid
Formula (C₁₄H₂₁NO₁₄S)n
Color Off-white to light yellow
SMILES

O=S(O)=O.O=S(O)=O.OC([C@@H]1[C@@H](OC)[C@H](O)[C@@H](O)[C@H](O[C@@H]2[C@@H](NC(C)=O)[C@H](OC)O[C@H](CO[R])[C@@H]2O[R])O1)=O.[R].[R].[=].[=].[R2=].[R1=].[n].[or]
Synonyms

Chondroitin polysulfate (from chicken)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (Need ultrasonic)

View the Complete Stock Solution Preparation Table

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang H, et al. Comparative Analysis of the Bioactive Compounds in Chicken Cartilage: Protective Effects of Chondroitin Sulfate and Type II Collagen Peptides Against Osteoarthritis Involve Gut Microbiota. Front Nutr. 2022;9:843360. Published 2022 Mar 30. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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Chondroitin sulfate (from chicken)

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