Chondroitin sulfate sodium (from bovine)  (Synonyms: Chondroitin polysulfate sodium (from bovine))

Chondroitin sulfate (Chondroitin polysulfate) sodium (from bovine)) is a sulfated linear polysaccharide extracted from bovine sources, belonging to glycosaminoglycans. Chondroitin sulfate sodium (from bovine) inhibits osteoclast-mediated bone resorption and exhibits antioxidant activity, which is negatively correlated with molecular weight. Chondroitin sulfate sodium (from bovine) can be used in studies related to osteoarthritis^[1][2].

Chondroitin sulfate sodium (from bovine) (1-1000 μg/mL; 7 days) reduces the formation of TRAP-positive multinucleated osteoclasts derived from human peripheral blood mononuclear cells only at the concentration of 1000 μg/mL^[1].
Chondroitin sulfate sodium (from bovine) (1-1000 μg/mL; 10 days) potently and persistently inhibits the bone resorptive activity of osteoclasts derived from human peripheral blood mononuclear cells^[1].
Chondroitin sulfate sodium (from bovine) exhibits concentration-dependent in vitro antioxidant activity. Among these fractions, the lowest molecular weight component (BCS-II-4, 19.7 kDa) shows the strongest scavenging activity against superoxide anions, DPPH radicals and hydroxyl radicals, as well as the highest ferric ion reducing power^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(C₁₄H₂₁NO₁₄SNa)n

9082-07-9

Solid

White to off-white

O=S(O)=O.O=S(O)=O.OC([C@@H]1[C@@H](OC)[C@H](O)[C@@H](O)[C@H](O[C@@H]2[C@@H](NC(C)=O)[C@H](OC)O[C@H](CO[R])[C@@H]2O[R])O1)=O.[Na+].[R].[R].[=].[=].[R2=].[R1=].[n].[or]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Cantley MD, et al. Comparison of the ability of chondroitin sulfate derived from bovine, fish and pigs to suppress human osteoclast activity in vitro. Inflammopharmacology. 2013;21(6):407-412.

  [2]. Zou Z, et al. Preparation of chondroitin sulfates with different molecular weights from bovine nasal cartilage and their antioxidant activities. Int J Biol Macromol. 2020;152:1047-1055.