Dermatan sulphate sodium
Based on 1 publication(s) in Google Scholar
Dermatan sulphate sodium is an oral active glycosaminoglycan and thrombin inactivator with antithrombotic activity. It selectively catalyzes the heparin cofactor II-mediated inactivation of thrombin without interacting with antithrombin III. Dermatan sulphate sodium promotes stem cell differentiation, exhibits high bioavailability, and alleviates pulmonary fibrosis injury induced by Bleomycin (HY-108345). Dermatan sulphate sodium can be used in research related to cardiovascular diseases, inflammation, and stem cell differentiation.
For research use only. We do not sell to patients.
- Purity: 95.4%
- CAS No.: 54328-33-5
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Dermatan sulphate sodium
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Biological Activity
Dermatan sulphate (10 μg/mL, 7 days) sodium promoted neuronal differentiation and migration, but did not affect neurite outgrowth in hNSCs[3]. Dermatan sulphate (100 μg/mL, 12 days) sodium promoted neuronal differentiation and enhanced neurite outgrowth in mESCs[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human neural stem cells (hNSCs, from 14-week human fetal cerebral cortex)
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Concentration:10 μg/mL
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Incubation Time:7 days
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Result:Significantly increased expression of neuronal markers (DCX, β-III-Tubulin).
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Cell Line:R1 mouse embryonic stem cells (mESCs, mouse, undifferentiated)
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Concentration:100 μg/mL
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Incubation Time:12 days
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Result:Significantly enhanced p-Erk1/2 expression.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Bleomycin (HY-108345)-induced pulmonary fibrosis model in C57 mice[2]
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Dosage:5.3 mg/kg
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Administration:Oral gavage (p.o.), once daily for 28 days
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Result:Significantly reduced lung index, alleviated pulmonary edema, inflammatory infiltration, alveolar damage and collagen deposition; Reduced lung hydroxyproline and plasma fibrinogen levels; Increased plasma tPA levels.
Chemical Information
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CAS No. 54328-33-5
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Appearance Solid
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Color White to off-white
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SMILES
N/A
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Structure Classification
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Initial Source
mammals and bacteria
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochemistry
The Crystal Structure of Acanthamoeba Polyphaga Mimivirus R655 and Its Potential Glycosaminoglycan Glycosyltransferase Activity. [Abstract]2025 Jul 1;64(13):2737-2744. PMID: 40545624
Solvent & Solubility
H2O : 100 mg/mL (Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Nenci GG. Dermatan sulphate as an antithrombotic drug. Pathophysiol Haemost Thromb. 2002 Sep-Dec;32(5-6):303-7. [Content Brief]
[2]. Xu J, et al. Effect of dermatan sulphate on a C57-mouse model of pulmonary fibrosis. J Int Med Res. 2019 Jun;47(6):2655-2665. [Content Brief]
[3]. Ogura C, et al. Dermatan sulphate promotes neuronal differentiation in mouse and human stem cells. J Biochem. 2021 Feb 6;169(1):55-64. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dermatan sulphate sodium Related Classifications
HY-N8278 Related Classifications
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