JNK2-IN-1
JNK2-IN-1 (Compound J27) is a JNK2 inhibitor (Kds: 79.2 μM). JNK2-IN-1 has anti-inflammatory activity. JNK2-IN-1 decreases the release of TNF-α and IL-6 through inhibiting the activation of NF-κB/MAPK pathway. JNK2-IN-1 alleviates the symptoms of LPS-induced acute lung injury (ALI) and sepsis.
For research use only. We do not sell to patients.
- CAS No.: 2998941-15-2
- Formula: C30H26N4O5
- Molecular Weight:522.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Kd: 79.2 μM[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| J774.A1 | IC50 |
5.3 μM
Compound: J27
|
Antiinflammatory activity against mouse J774A.1 cells assessed as inhibition of LPS-stimulated TNFalpha release measured after 30 mins by ELISA
Antiinflammatory activity against mouse J774A.1 cells assessed as inhibition of LPS-stimulated TNFalpha release measured after 30 mins by ELISA
|
[PMID: 37643372] |
| J774.A1 | IC50 |
7.11 μM
Compound: J27
|
Antiinflammatory activity against mouse J774A.1 cells assessed as inhibition of LPS-stimulated IL6 release measured after 30 mins by ELISA
Antiinflammatory activity against mouse J774A.1 cells assessed as inhibition of LPS-stimulated IL6 release measured after 30 mins by ELISA
|
[PMID: 37643372] |
| THP-1 | IC50 |
0.22 μM
Compound: J27
|
Antiinflammatory activity against human THP-1 cells assessed as inhibition of LPS-stimulated IL6 release measured after 30 mins by ELISA
Antiinflammatory activity against human THP-1 cells assessed as inhibition of LPS-stimulated IL6 release measured after 30 mins by ELISA
|
[PMID: 37643372] |
Chemical Information
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CAS No. 2998941-15-2
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Molecular Weight 522.55
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Formula C30H26N4O5
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SMILES
CC1=CC=C(C=C1)N2C(C=C(C(C(NC3=CC=C(OC4=C5C(C=C(C(OC)=C5)OC)=NC=C4)C=C3)=O)=N2)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)