5-LOX-IN-6
5-LOX-IN-6 (compound 11a) is a direct and reversible inhibitor of 5-lipoxygenase (5-LO). 5-LOX-IN-6 inhibits 5-LO activity in human neutrophils and recombinant human 5-LO with IC50 values of 0.23 and 0.086 µM, respectively. 5-LOX-IN-6 prevents leukotriene biosynthesis. 5-LOX-IN-6 can be used for inflammatory and allergic disorders research.
For research use only. We do not sell to patients.
- CAS No.: 1159576-98-3
- Formula: C22H18ClNO3
- Molecular Weight:379.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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All Leukotriene Receptor Isoforms
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Biological Activity
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5-LO |
LTB4 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.6 μM
Compound: S17
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Inhibition of mPGES-1 in IL-1beta-stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 formation incubated for 15 mins using PGH2 substrate by RP-HPLC method
Inhibition of mPGES-1 in IL-1beta-stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 formation incubated for 15 mins using PGH2 substrate by RP-HPLC method
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[PMID: 26088337] |
| A549 | IC50 |
0.6 μM
Compound: 7a
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Inhibition of mPGES1 in IL1-beta induced human A549 cell microsomal membrane assessed as blockade of conversion of PGH2 to PGE2
Inhibition of mPGES1 in IL1-beta induced human A549 cell microsomal membrane assessed as blockade of conversion of PGH2 to PGE2
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[PMID: 19884011] |
| A549 | IC50 |
2 μM
Compound: 7a
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Inhibition of mPGES1 in IL1-beta induced human A549 cells assessed as PGE2 production preincubated for 10 mins
Inhibition of mPGES1 in IL1-beta induced human A549 cells assessed as PGE2 production preincubated for 10 mins
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[PMID: 19884011] |
5-LOX-IN-6 (compound 11a) (0-10 µM) efficiently blocks 5-LO product formation in human whole blood assays (IC50=0.83-1.6 µM)[1].
5-LOX-IN-6 (0-10 µM) fails to block A23187 (HY-N6687, 2.5 µM)-induced translocation of 5-LO in neutrophils[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar Han rats (220-230 g, n=10 per group)[1]
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Dosage:4 mg/kg
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Administration:IP, 30 min before λ-carrageenan administration. Rats were anaesthetized and λ-carrageenan (HY-N9470) was injected into the pleural cavity.
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Result:significantly reduced the inflammatory reaction measured as exudate volume (77%), inflammatory cell numbers (40%), and LTB4 levels (49%) in the pleural exudates.
Chemical Information
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CAS No. 1159576-98-3
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Molecular Weight 379.84
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Formula C22H18ClNO3
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SMILES
O=C(C1=C(CC2=CC(Cl)=CC=C2)NC3=C1C=C(C4=C3C=CC=C4)O)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5-LOX-IN-6 Related Classifications
HY-120502 Related Classifications
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